|Description: Forkhead box protein O4 (Fork head domain transcription factor AFX1).|
Synonyms: AFX, AFX1, MLLT7
Ensembl ID: ENSG00000184481
UniprotKB/SwissProt: FOXO4_HUMAN (P98177)
Function: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation.