Regulatory Network in Protein Phosphorylation
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Substrate: FOXO4

Description: Forkhead box protein O4 (Fork head domain transcription factor AFX1).

Synonyms: AFX, AFX1, MLLT7

Ensembl ID: ENSG00000184481

UniprotKB/SwissProt: FOXO4_HUMAN (P98177)

Function: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation.
PDB:1E17
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of FOXO4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1FOXO4FOXO4_HUMANT32RPRSC T WPLPR 31.22% Phospho.ELM 7.0View   
2FOXO4FOXO4_HUMANT32RPRSC T WPLPR 31.22%AKT2 HPRD:02070(in vivo)  ViewAnalyzing
3FOXO4FOXO4_HUMANT32RPRSC T WPLPR 31.22%AKT1 HPRD:02070(in vitro;in vivo)  ViewAnalyzing
4FOXO4FOXO4_HUMANT32RPRSC T WPLPR 31.22%AKT1(PKB)  Swiss-Prot 55.0  ViewAnalyzing
5FOXO4FOXO4_HUMANS111YAELI S QAIES 26.61% Swiss-Prot 55.0 View   
6FOXO4FOXO4_HUMANS197RRRAA S MDSSS 23.34%AKT1 HPRD:02070(in vitro)  ViewAnalyzing
7FOXO4FOXO4_HUMANS197RRRAA S MDSSS 23.34%AKT_group Phospho.ELM 7.0 ViewAnalyzing
8FOXO4FOXO4_HUMANS197RRRAA S MDSSS 23.34%AKT1(PKB)  Swiss-Prot 55.0  ViewAnalyzing
9FOXO4FOXO4_HUMANS200AASMD S SSKLL 28.06% Swiss-Prot 55.0 View   
10FOXO4FOXO4_HUMANS262RPRSS S NASSV 37.35%AKT1 HPRD:02070(in vitro)  ViewAnalyzing
11FOXO4FOXO4_HUMANS262RPRSS S NASSV 37.35%AKT_group Phospho.ELM 7.0 ViewAnalyzing
12FOXO4FOXO4_HUMANS262RPRSS S NASSV 37.35%AKT1(PKB)  Swiss-Prot 55.0  ViewAnalyzing
13FOXO4FOXO4_HUMANT451PKALG T PVLTP 15.86%AKT1 HPRD:02070(in vivo)  ViewAnalyzing
14FOXO4FOXO4_HUMANT451PKALG T PVLTP 15.86%JNK1(MAPK8) Phospho.ELM 7.0 ViewAnalyzing
15FOXO4FOXO4_HUMANT451PKALG T PVLTP 15.86%AKT_group Phospho.ELM 7.0 ViewAnalyzing
16FOXO4FOXO4_HUMANT451PKALG T PVLTP 15.86%JNK2(MAPK9) Phospho.ELM 7.0 ViewAnalyzing
17FOXO4FOXO4_HUMANT455GTPVL T PPTEA 27.70%AKT1 HPRD:02070(in vivo)  ViewAnalyzing
18FOXO4FOXO4_HUMANT455GTPVL T PPTEA 27.70%JNK1(MAPK8) Phospho.ELM 7.0 ViewAnalyzing
19FOXO4FOXO4_HUMANT455GTPVL T PPTEA 27.70%JNK2(MAPK9) Phospho.ELM 7.0 ViewAnalyzing