Regulatory Network in Protein Phosphorylation
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Substrate: FRAP1

Description: FKBP12-rapamycin complex-associated protein (FK506-binding protein 12-rapamycin complex-associated protein 1) (Rapamycin target protein)(RAPT1) (Mammalian target of rapamycin) (mTOR).

Synonyms: FRAP, FRAP2

Ensembl ID: ENSG00000198793

UniprotKB/SwissProt: FRAP_HUMAN (P42345)

Function: Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1AUE
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of FRAP1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1FRAP1FRAP_HUMANT1162HPIVR T LDQSP 24.64% Swiss-Prot 55.0 View   
2FRAP1FRAP_HUMANT2446RSRTR T DSYSA 28.78%AKT_group Phospho.ELM 7.0 ViewAnalyzing
3FRAP1FRAP_HUMANT2446RSRTR T DSYSA 28.78%AKT1 HPRD:03134(in vitro)  ViewAnalyzing
4FRAP1FRAP_HUMANT2446RSRTR T DSYSA 28.78%p70S6K Phospho.ELM 7.0  ViewAnalyzing
5FRAP1FRAP_HUMANS2448RTRTD S YSAGQ 22.00%AKT_group Phospho.ELM 7.0 ViewAnalyzing
6FRAP1FRAP_HUMANS2448RTRTD S YSAGQ 22.00%AKT1 HPRD:03134(in vitro)  ViewAnalyzing
7FRAP1FRAP_HUMANS2448RTRTD S YSAGQ 22.00%p70S6K Phospho.ELM 7.0  ViewAnalyzing
8FRAP1FRAP_HUMANS2478TTVPE S IHSFI 21.38% Swiss-Prot 55.0 (Similarity)View   
9FRAP1FRAP_HUMANS2481PESIH S FIGDG 19.52%FRAP HPRD:03134(in vitro;in vivo)  ViewAnalyzing
10FRAP1FRAP_HUMANS2481PESIH S FIGDG 19.52%FRAP(mTOR) Phospho.ELM 7.0 ViewAnalyzing
11FRAP1FRAP_HUMANS2481PESIH S FIGDG 19.52% Swiss-Prot 55.0 (Similarity)View