|Description: Glycogen synthase kinase-3 beta (EC 220.127.116.11) (GSK-3 beta).|
Ensembl ID: ENSG00000082701
UniprotKB/SwissProt: GSK3B_HUMAN (P49841)
Function: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: