Regulatory Network in Protein Phosphorylation
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Substrate: GSK3B

Description: Glycogen synthase kinase-3 beta (EC 2.7.11.26) (GSK-3 beta).

Ensembl ID: ENSG00000082701

UniprotKB/SwissProt: GSK3B_HUMAN (P49841)

Function: Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1GNG
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of GSK3B

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1GSK3BGSK3B_HUMANT7SGRPR T TSFAE 29.49% Swiss-Prot 55.0 (Similarity)View   
2GSK3BGSK3B_HUMANS9RPRTT S FAESC 23.11%SGK3 HPRD:05418(in vitro)  ViewAnalyzing
3GSK3BGSK3B_HUMANS9RPRTT S FAESC 23.11%PKACa HPRD:05418(in vivo)  ViewAnalyzing
4GSK3BGSK3B_HUMANS9RPRTT S FAESC 23.11%RSK_group Phospho.ELM 7.0 ViewAnalyzing
5GSK3BGSK3B_HUMANS9RPRTT S FAESC 23.11%PKA_group Phospho.ELM 7.0 ViewAnalyzing
6GSK3BGSK3B_HUMANS9RPRTT S FAESC 23.11%AKT1 HPRD:05418(in vivo)  ViewAnalyzing
7GSK3BGSK3B_HUMANS9RPRTT S FAESC 23.11%AKT1(PKB) Swiss-Prot 55.0  ViewAnalyzing
8GSK3BGSK3B_HUMANS21PVQQP S AFGSM 31.71%SGK3 HPRD:05418(in vivo)  ViewAnalyzing
9GSK3BGSK3B_HUMANS21PVQQP S AFGSM 31.71%SGK_group Phospho.ELM 7.0 ViewAnalyzing
10GSK3BGSK3B_HUMANT43TTVVA T PGQGP 19.15%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
11GSK3BGSK3B_HUMANT43TTVVA T PGQGP 19.15%Erk1(MAPK3) Phospho.ELM 7.0 ViewAnalyzing
12GSK3BGSK3B_HUMANS215GEPNV S YICSR 18.54% Swiss-Prot 55.0 (Similarity)View   
13GSK3BGSK3B_HUMANY216EPNVS Y ICSRY 11.15% Swiss-Prot 55.0 View   
14GSK3BGSK3B_HUMANY216EPNVS Y ICSRY 11.15%MAP2K1 Phospho.ELM 7.0  ViewAnalyzing
15GSK3BGSK3B_HUMANY216EPNVS Y ICSRY 11.15% HPRD:05418(invivo)View   
16GSK3BGSK3B_HUMANS219VSYIC S RYYRA 17.48% Swiss-Prot 55.0 (Similarity)View   
17GSK3BGSK3B_HUMANS389IQAAA S TPTNA 30.14% HPRD:05418(in vitro)View   
18GSK3BGSK3B_HUMANS389IQAAA S TPTNA 30.14% Swiss-Prot 55.0 (Similarity)View   
19GSK3BGSK3B_HUMANT390QAAAS T PTNAT 29.43% Swiss-Prot 55.0 View   
20GSK3BGSK3B_HUMANT390QAAAS T PTNAT 29.43% Phospho.ELM 7.0View   
21GSK3BGSK3B_HUMANT390QAAAS T PTNAT 29.43% HPRD:05418(in vivo)View   
22GSK3BGSK3B_HUMANT395TPTNA T AASDA 25.48% Swiss-Prot 55.0 (Similarity)View   
23GSK3BGSK3B_HUMANT402ASDAN T GDRGQ 42.03% Phospho.ELM 7.0View