Regulatory Network in Protein Phosphorylation
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Substrate: HMOX1

Description: Heme oxygenase 1 (EC 1.14.99.3) (HO-1).

Synonyms: HO, HO1

Ensembl ID: ENSG00000100292

UniprotKB/SwissProt: HMOX1_HUMAN (P09601)

Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Microsome. Endoplasmic reticulum.
PDB:1N3U
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HMOX1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HMOX1HMOX1_HUMANS188RSRMN S LEMTP 19.16%AKT1 HPRD:00782(in vivo)  ViewAnalyzing
2HMOX1HMOX1_HUMANS229DTKDQ S PSRAP 34.67% Swiss-Prot 55.0 View   
3HMOX1HMOX1_HUMANS229DTKDQ S PSRAP 34.67% Phospho.ELM 7.0View   
4HMOX1HMOX1_HUMANS231KDQSP S RAPGL 46.45% Phospho.ELM 7.0View