|Description: Heme oxygenase 1 (EC 188.8.131.52) (HO-1).|
Synonyms: HO, HO1
Ensembl ID: ENSG00000100292
UniprotKB/SwissProt: HMOX1_HUMAN (P09601)
Function: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Microsome. Endoplasmic reticulum.