Regulatory Network in Protein Phosphorylation
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Substrate: HSPB1

Description: Heat shock protein beta-1 (HspB1) (Heat shock 27 kDa protein) (HSP 27)(Stress-responsive protein 27) (SRP27) (Estrogen-regulated 24 kDaprotein) (28 kDa heat shock protein).

Synonyms: HSP27

Ensembl ID: ENSG00000106211

UniprotKB/SwissProt: HSPB1_HUMAN (P04792)

Function: Involved in stress resistance and actin organization.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HSPB1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HSPB1HSPB1_HUMANS15LLRGP S WDPFR 47.11% Swiss-Prot 55.0 View   
2HSPB1HSPB1_HUMANS15LLRGP S WDPFR 47.11%MAPKAPK2 Phospho.ELM 7.0  ViewAnalyzing
3HSPB1HSPB1_HUMANS15LLRGP S WDPFR 47.11%MAPKAPK2 HPRD:09076(in vitro;in vivo)  ViewAnalyzing
4HSPB1HSPB1_HUMANS15LLRGP S WDPFR 47.11%MAPKAPK3 HPRD:09076(in vitro)  ViewAnalyzing
5HSPB1HSPB1_HUMANS15LLRGP S WDPFR 47.11%PKA_group Phospho.ELM 7.0 ViewAnalyzing
6HSPB1HSPB1_HUMANS15LLRGP S WDPFR 47.11% HPRD:09076(in vivo)View   
7HSPB1HSPB1_HUMANS26DWYPH S RLFDQ 26.61% Swiss-Prot 55.0 (Similarity)View   
8HSPB1HSPB1_HUMANS65PAAIE S PAVAA 16.43% Swiss-Prot 55.0 View   
9HSPB1HSPB1_HUMANS65PAAIE S PAVAA 16.43% Phospho.ELM 7.0View   
10HSPB1HSPB1_HUMANS78YSRAL S RQLSS 19.59%MAPKAPK2 Phospho.ELM 7.0  ViewAnalyzing
11HSPB1HSPB1_HUMANS78YSRAL S RQLSS 19.59% HPRD:09076(in vivo)View   
12HSPB1HSPB1_HUMANS78YSRAL S RQLSS 19.59%MAPKAPK3 HPRD:09076(in vitro)  ViewAnalyzing
13HSPB1HSPB1_HUMANS78YSRAL S RQLSS 19.59%p70S6Kb Phospho.ELM 7.0  ViewAnalyzing
14HSPB1HSPB1_HUMANS78YSRAL S RQLSS 19.59%MAPKAPK2 HPRD:09076(in vitro)  ViewAnalyzing
15HSPB1HSPB1_HUMANS78YSRAL S RQLSS 19.59% Swiss-Prot 55.0 View   
16HSPB1HSPB1_HUMANS82LSRQL S SGVSE 19.39%PKD1 Phospho.ELM 7.0  ViewAnalyzing
17HSPB1HSPB1_HUMANS82LSRQL S SGVSE 19.39%AKT_group Phospho.ELM 7.0 ViewAnalyzing
18HSPB1HSPB1_HUMANS82LSRQL S SGVSE 19.39% HPRD:09076(in vivo)View   
19HSPB1HSPB1_HUMANS82LSRQL S SGVSE 19.39% Swiss-Prot 55.0 View   
20HSPB1HSPB1_HUMANS82LSRQL S SGVSE 19.39%MAPKAPK2 HPRD:09076(in vitro;in vivo)  ViewAnalyzing
21HSPB1HSPB1_HUMANS82LSRQL S SGVSE 19.39%MAPKAPK2 Phospho.ELM 7.0  ViewAnalyzing
22HSPB1HSPB1_HUMANS82LSRQL S SGVSE 19.39%MAPKAPK3 HPRD:09076(in vitro)  ViewAnalyzing
23HSPB1HSPB1_HUMANS82LSRQL S SGVSE 19.39%p70S6Kb Phospho.ELM 7.0  ViewAnalyzing
24HSPB1HSPB1_HUMANS83SRQLS S GVSEI 52.37% Swiss-Prot 55.0 View   
25HSPB1HSPB1_HUMANS83SRQLS S GVSEI 52.37% HPRD:09076(in vivo)View   
26HSPB1HSPB1_HUMANS83SRQLS S GVSEI 52.37% Phospho.ELM 7.0View   
27HSPB1HSPB1_HUMANS86LSSGV S EIRHT 30.72% Phospho.ELM 7.0View   
28HSPB1HSPB1_HUMANT91SEIRH T ADRWR 22.02% Phospho.ELM 7.0View