|Description: Interleukin-1 receptor-associated kinase 1 (EC 188.8.131.52) (IRAK-1).|
Ensembl ID: ENSG00000184216
UniprotKB/SwissProt: IRAK1_HUMAN (P51617)
Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: