Regulatory Network in Protein Phosphorylation
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Substrate: ITGB3

Description: Integrin beta-3 precursor (Platelet membrane glycoprotein IIIa)(GPIIIa) (CD61 antigen).

Synonyms: GP3A

Ensembl ID: ENSG00000056345

UniprotKB/SwissProt: ITB3_HUMAN (P05106)

Function: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
PDB:1JV2
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ITGB3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ITGB3ITB3_HUMANY773ANNPL Y KEATS 14.19%SRC HPRD:01428(in vitro;in vivo)  ViewAnalyzing
2ITGB3ITB3_HUMANY773ANNPL Y KEATS 14.19%Src Phospho.ELM 7.0  ViewAnalyzing
3ITGB3ITB3_HUMANY773ANNPL Y KEATS 14.19% Swiss-Prot 55.0 View   
4ITGB3ITB3_HUMANY773ANNPL Y KEATS 14.19%Syk Phospho.ELM 7.0  ViewAnalyzing
5ITGB3ITB3_HUMANT777LYKEA T STFTN 29.41%PDK1 Phospho.ELM 7.0  ViewAnalyzing
6ITGB3ITB3_HUMANT779KEATS T FTNIT 30.08%AKT1 HPRD:01428(in vitro)  ViewAnalyzing
7ITGB3ITB3_HUMANT779KEATS T FTNIT 30.08% HPRD:01428(in vitro)View   
8ITGB3ITB3_HUMANT779KEATS T FTNIT 30.08%PDK1 HPRD:01428(in vitro)  ViewAnalyzing
9ITGB3ITB3_HUMANT779KEATS T FTNIT 30.08%PDK1 Phospho.ELM 7.0  ViewAnalyzing
10ITGB3ITB3_HUMANT779KEATS T FTNIT 30.08%PDHK1 HPRD:01428(in vitro)  ViewAnalyzing
11ITGB3ITB3_HUMANT779KEATS T FTNIT 30.08%AKT1(PKB) Swiss-Prot 55.0  ViewAnalyzing
12ITGB3ITB3_HUMANT779KEATS T FTNIT 30.08%PDK1 Swiss-Prot 55.0   ViewAnalyzing
13ITGB3ITB3_HUMANY785FTNIT Y RGT 11.84%Syk Phospho.ELM 7.0  ViewAnalyzing
14ITGB3ITB3_HUMANY785FTNIT Y RGT 11.84% Swiss-Prot 55.0 View   
15ITGB3ITB3_HUMANY785FTNIT Y RGT 11.84%Src Phospho.ELM 7.0  ViewAnalyzing
16ITGB3ITB3_HUMANY785FTNIT Y RGT 11.84%SRC HPRD:01428(in vitro;in vivo)  ViewAnalyzing