|Description: Mitogen-activated protein kinase kinase kinase 11 (EC 220.127.116.11)(Mixed lineage kinase 3) (Src-homology 3 domain-containing proline-rich kinase).|
Synonyms: MLK3, PTK1, SPRK
Ensembl ID: ENSG00000173327
UniprotKB/SwissProt: M3K11_HUMAN (Q16584)
Function: Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1). Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Centrosome. Note=Location is cell cycle dependent.