|Description: Mitogen-activated protein kinase kinase kinase 5 (EC 184.108.40.206)(MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1).|
Synonyms: ASK1, MAPKKK5, MEKK5
Ensembl ID: ENSG00000197442
UniprotKB/SwissProt: M3K5_HUMAN (Q99683)
Function: Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: