Regulatory Network in Protein Phosphorylation
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Substrate: MAP3K5

Description: Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25)(MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1).

Synonyms: ASK1, MAPKKK5, MEKK5

Ensembl ID: ENSG00000197442

UniprotKB/SwissProt: M3K5_HUMAN (Q99683)

Function: Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:2CLQ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MAP3K5

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MAP3K5M3K5_HUMANS83RGRGS S VGGGS 27.83%AKT_group Phospho.ELM 7.0 ViewAnalyzing
2MAP3K5M3K5_HUMANS83RGRGS S VGGGS 27.83%Akt2(PKB beta) Phospho.ELM 7.0 ViewAnalyzing
3MAP3K5M3K5_HUMANS83RGRGS S VGGGS 27.83%AKT1 HPRD:03904(in vitro;in vivo)  ViewAnalyzing
4MAP3K5M3K5_HUMANT838NPCTE T FTGTL 14.35%PDK1 Phospho.ELM 7.0  ViewAnalyzing
5MAP3K5M3K5_HUMANT838NPCTE T FTGTL 14.35%MAP3K5 HPRD:03904(in vivo)  ViewAnalyzing
6MAP3K5M3K5_HUMANT838NPCTE T FTGTL 14.35% Swiss-Prot 55.0 View   
7MAP3K5M3K5_HUMANT842ETFTG T LQYMA 13.97% HPRD:03904(in vitro;in vivo)View   
8MAP3K5M3K5_HUMANS958ALSAG S NEYLR 26.63% Swiss-Prot 55.0 (Similarity)View   
9MAP3K5M3K5_HUMANS966YLRSI S LPVPV 28.06%MAP3K5 Phospho.ELM 7.0  ViewAnalyzing
10MAP3K5M3K5_HUMANS966YLRSI S LPVPV 28.06% Swiss-Prot 55.0 View   
11MAP3K5M3K5_HUMANS966YLRSI S LPVPV 28.06% HPRD:03904(in vitro)View   
12MAP3K5M3K5_HUMANS1033HSAPP S PEEKD 43.83% Phospho.ELM 7.0View   
13MAP3K5M3K5_HUMANS1033HSAPP S PEEKD 43.83% Swiss-Prot 55.0 View