Regulatory Network in Protein Phosphorylation
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Substrate: MAP3K8

Description: Mitogen-activated protein kinase kinase kinase 8 (EC 2.7.11.25) (COTproto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osakathyroid oncogene) (Tumor progression locus 2) (TPL-2).

Synonyms: COT, ESTF

Ensembl ID: ENSG00000107968

UniprotKB/SwissProt: M3K8_HUMAN (P41279)

Function: Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MAP3K8

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MAP3K8M3K8_HUMANT290KDLRG T EIYMS 16.87% Phospho.ELM 7.0View   
2MAP3K8M3K8_HUMANS400QPRCQ S LDSAL 37.46%AKT1 HPRD:01863(in vivo)  ViewAnalyzing
3MAP3K8M3K8_HUMANS400QPRCQ S LDSAL 37.46%AKT_group Phospho.ELM 7.0 ViewAnalyzing
4MAP3K8M3K8_HUMANS413RKRLL S RKELE 45.99% Phospho.ELM 7.0View   
5MAP3K8M3K8_HUMANS413RKRLL S RKELE 45.99%AKT1 HPRD:01863(in vivo)  ViewAnalyzing