|Description: Mitogen-activated protein kinase kinase kinase 8 (EC 184.108.40.206) (COTproto-oncogene serine/threonine-protein kinase) (C-COT) (Cancer Osakathyroid oncogene) (Tumor progression locus 2) (TPL-2).|
Synonyms: COT, ESTF
Ensembl ID: ENSG00000107968
UniprotKB/SwissProt: M3K8_HUMAN (P41279)
Function: Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.