Regulatory Network in Protein Phosphorylation
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Substrate: MDM2

Description: E3 ubiquitin-protein ligase Mdm2 (EC 6.3.2.-) (p53-binding proteinMdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

Ensembl ID: ENSG00000135679

UniprotKB/SwissProt: MDM2_HUMAN (Q00987)

Function: Inhibits TP53/p53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Functions as a ubiquitin ligase E3, in the presence of E1 and E2, toward p53 and itself. Permits the nuclear export of p53 and targets it for proteasome-mediated proteolysis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleoplasm. Cytoplasm. Nucleus, nucleolus. Note=Expressed predominantly in the nucleoplasm. Interaction with ARF(P14) results in the localization of both proteins to the nucleolus. The nucleolar localization signals in both ARF(P14) and MDM2 ma
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of MDM2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1MDM2MDM2_HUMANS157LVSRP S TSSRR 39.55% Phospho.ELM 7.0View   
2MDM2MDM2_HUMANS166RRRAI S ETEEN 37.16%AKT_group Phospho.ELM 7.0 ViewAnalyzing
3MDM2MDM2_HUMANS166RRRAI S ETEEN 37.16%DAPK3 Phospho.ELM 7.0  ViewAnalyzing
4MDM2MDM2_HUMANS172ETEEN S DELSG 35.42%AKT1 HPRD:01272(in vitro;in vivo)  ViewAnalyzing
5MDM2MDM2_HUMANS186RKRHK S DSISL 30.39%AKT_group Phospho.ELM 7.0 ViewAnalyzing
6MDM2MDM2_HUMANS188RHKSD S ISLSF 22.59%AKT_group Phospho.ELM 7.0 ViewAnalyzing
7MDM2MDM2_HUMANS192DSISL S FDESL 24.70%AKT1 HPRD:01272(in vitro;in vivo)  ViewAnalyzing
8MDM2MDM2_HUMANS240WLDQD S VSDQF 20.21% Phospho.ELM 7.0View   
9MDM2MDM2_HUMANS242DQDSV S DQFSV 29.64% Phospho.ELM 7.0View   
10MDM2MDM2_HUMANS246VSDQF S VEFEV 18.33% Phospho.ELM 7.0View   
11MDM2MDM2_HUMANS260DSEDY S LSEEG 37.43% Phospho.ELM 7.0View   
12MDM2MDM2_HUMANS262EDYSL S EEGQE 27.88% Phospho.ELM 7.0View   
13MDM2MDM2_HUMANS269EGQEL S DEDDE 37.90% Phospho.ELM 7.0View   
14MDM2MDM2_HUMANY394QESED Y SQPST 12.73%ABL1 HPRD:01272(in vitro;in vivo)  ViewAnalyzing
15MDM2MDM2_HUMANY394QESED Y SQPST 12.73%ABL1 Phospho.ELM 7.0  ViewAnalyzing
16MDM2MDM2_HUMANS395ESEDY S QPSTS 48.19%ATM Phospho.ELM 7.0  ViewAnalyzing
17MDM2MDM2_HUMANS401QPSTS S SIIYS 26.16%ATM HPRD:01272(in vitro;in vivo)  ViewAnalyzing
18MDM2MDM2_HUMANS407SIIYS S QEDVK 22.18%ATR Phospho.ELM 7.0  ViewAnalyzing