Regulatory Network in Protein Phosphorylation
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Substrate: NOS3

Description: Nitric oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS typeIII) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

Ensembl ID: ENSG00000164867

UniprotKB/SwissProt: NOS3_HUMAN (P29474)

Function: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
PDB:1M9J
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of NOS3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1NOS3NOS3_HUMANT495ITRKK T FKEVA 42.87% Phospho.ELM 7.0View   
2NOS3NOS3_HUMANT495ITRKK T FKEVA 42.87% Swiss-Prot 55.0 (Similarity)View   
3NOS3NOS3_HUMANS615KIRFN S ISCSD 17.11%AKT_group Phospho.ELM 7.0 ViewAnalyzing
4NOS3NOS3_HUMANS633RKRKE S SNTDS 31.74% Swiss-Prot 55.0 (Similarity)View   
5NOS3NOS3_HUMANS633RKRKE S SNTDS 31.74%PKA_group Phospho.ELM 7.0 ViewAnalyzing
6NOS3NOS3_HUMANT1175TSRIR T QSFSL 26.62% Swiss-Prot 55.0 (Similarity)View   
7NOS3NOS3_HUMANS1177RIRTQ S FSLQE 19.05% Swiss-Prot 55.0 (Similarity)View   
8NOS3NOS3_HUMANS1177RIRTQ S FSLQE 19.05%AKT_group Phospho.ELM 7.0 ViewAnalyzing
9NOS3NOS3_HUMANS1177RIRTQ S FSLQE 19.05%AMPK_group Phospho.ELM 7.0 ViewAnalyzing
10NOS3NOS3_HUMANS1177RIRTQ S FSLQE 19.05%AKT1 HPRD:01224(in vitro)  ViewAnalyzing
11NOS3NOS3_HUMANS1179RTQSF S LQERQ 34.10%AKT_group Phospho.ELM 7.0 ViewAnalyzing