|Description: Nitric oxide synthase, endothelial (EC 184.108.40.206) (EC-NOS) (NOS typeIII) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).|
Ensembl ID: ENSG00000164867
UniprotKB/SwissProt: NOS3_HUMAN (P29474)
Function: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. No mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.