|Description: Programmed cell death protein 4 (Nuclear antigen H731-like)(Neoplastic transformation inhibitor protein) (Protein 197/15a).|
Ensembl ID: ENSG00000150593
UniprotKB/SwissProt: PDCD4_HUMAN (Q53EL6)
Function: Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Inhibits the helicase activity of EIF4A and cap-dependent translation. Binds RNA (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions. Exported from the nucleus in the absence of serum.