Regulatory Network in Protein Phosphorylation
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Substrate: PDCD4

Description: Programmed cell death protein 4 (Nuclear antigen H731-like)(Neoplastic transformation inhibitor protein) (Protein 197/15a).

Synonyms: H731

Ensembl ID: ENSG00000150593

UniprotKB/SwissProt: PDCD4_HUMAN (Q53EL6)

Function: Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Inhibits the helicase activity of EIF4A and cap-dependent translation. Binds RNA (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions. Exported from the nucleus in the absence of serum.
PDB:2GGF
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PDCD4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PDCD4PDCD4_HUMANS67RLRKN S SRDSG 29.77%AKT_group Phospho.ELM 7.0 ViewAnalyzing
2PDCD4PDCD4_HUMANS76SGRGD S VSDSG 26.75% Swiss-Prot 55.0 View   
3PDCD4PDCD4_HUMANS76SGRGD S VSDSG 26.75% Phospho.ELM 7.0View   
4PDCD4PDCD4_HUMANT93GLTVP T SPKGR 54.01% Swiss-Prot 55.0 View   
5PDCD4PDCD4_HUMANS94LTVPT S PKGRL 20.67% Phospho.ELM 7.0View   
6PDCD4PDCD4_HUMANS94LTVPT S PKGRL 20.67% Swiss-Prot 55.0 View   
7PDCD4PDCD4_HUMANY152QENCV Y ETVVL 14.21% Swiss-Prot 55.0 View   
8PDCD4PDCD4_HUMANY405QMKRG Y ERIYN 13.18% Phospho.ELM 7.0View   
9PDCD4PDCD4_HUMANS457RKRFV S EGDGG 32.90% Swiss-Prot 55.0 View   
10PDCD4PDCD4_HUMANS457RKRFV S EGDGG 32.90% HPRD:10549(in vitro)View   
11PDCD4PDCD4_HUMANS457RKRFV S EGDGG 32.90%AKT_group Phospho.ELM 7.0 ViewAnalyzing