Regulatory Network in Protein Phosphorylation
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Substrate: PEA15

Description: Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes)(PED).

Ensembl ID: ENSG00000162734

UniprotKB/SwissProt: PEA15_HUMAN (Q15121)

Function: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Note=Associated with microtubules.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PEA15

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PEA15PEA15_HUMANT6MAEYG T LLQDL 24.32% Swiss-Prot 55.0 View   
2PEA15PEA15_HUMANS25LEQLK S ACKED 47.71% Swiss-Prot 55.0 View   
3PEA15PEA15_HUMANS104LTRIP S AKKYK 50.80%PKC_group Phospho.ELM 7.0 ViewAnalyzing
4PEA15PEA15_HUMANS104LTRIP S AKKYK 50.80%PKCa HPRD:04579(in vitro)  ViewAnalyzing
5PEA15PEA15_HUMANS104LTRIP S AKKYK 50.80% Swiss-Prot 55.0 View   
6PEA15PEA15_HUMANY108PSAKK Y KDIIR 17.12% Swiss-Prot 55.0 View   
7PEA15PEA15_HUMANS116IIRQP S EEEII 49.67% Swiss-Prot 55.0 View   
8PEA15PEA15_HUMANS116IIRQP S EEEII 49.67%CaMK2g HPRD:04579(in vitro;in vivo)  ViewAnalyzing
9PEA15PEA15_HUMANS116IIRQP S EEEII 49.67%CaMK2_group Phospho.ELM 7.0 ViewAnalyzing
10PEA15PEA15_HUMANS116IIRQP S EEEII 49.67%AKT1 HPRD:04579(in vitro;in vivo)  ViewAnalyzing
11PEA15PEA15_HUMANS116IIRQP S EEEII 49.67%AKT_group Phospho.ELM 7.0 ViewAnalyzing