|Description: Astrocytic phosphoprotein PEA-15 (Phosphoprotein enriched in diabetes)(PED).|
Ensembl ID: ENSG00000162734
UniprotKB/SwissProt: PEA15_HUMAN (Q15121)
Function: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Note=Associated with microtubules.