Regulatory Network in Protein Phosphorylation
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Substrate: PFKFB2

Description: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (6PF-2-K/Fru-2,6-P2ASE heart-type isozyme) (PFK-2/FBPase-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase(EC 3.1.3.46)].

Ensembl ID: ENSG00000123836

UniprotKB/SwissProt: F262_HUMAN (O60825)

Function: Synthesis and degradation of fructose 2,6-bisphosphate.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PFKFB2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PFKFB2F262_HUMANS29SEKKC S WASYM 34.26%PKA_group  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2PFKFB2F262_HUMANS466RMRRN S FTPLS 28.78% Swiss-Prot 55.0 View   
3PFKFB2F262_HUMANS466RMRRN S FTPLS 28.78%AKT1 HPRD:01383(in vitro)  ViewAnalyzing
4PFKFB2F262_HUMANS466RMRRN S FTPLS 28.78%AMPK_group Phospho.ELM 7.0 ViewAnalyzing
5PFKFB2F262_HUMANS466RMRRN S FTPLS 28.78%AMPKa2 HPRD:01383(in vitro)  ViewAnalyzing
6PFKFB2F262_HUMANS466RMRRN S FTPLS 28.78%AMPKa1 HPRD:01383(in vitro)  ViewAnalyzing
7PFKFB2F262_HUMANS466RMRRN S FTPLS 28.78%AKT_group Phospho.ELM 7.0 ViewAnalyzing
8PFKFB2F262_HUMANS466RMRRN S FTPLS 28.78%PKACa HPRD:01383(in vitro)  ViewAnalyzing
9PFKFB2F262_HUMANT475LSSSN T IRRPR 20.15%PKC_group  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
10PFKFB2F262_HUMANT475LSSSN T IRRPR 20.15%PKCa HPRD:01383(in vitro)  ViewAnalyzing
11PFKFB2F262_HUMANS483RPRNY S VGSRP 24.45%AKT_group Phospho.ELM 7.0 ViewAnalyzing
12PFKFB2F262_HUMANS483RPRNY S VGSRP 24.45%AKT1 HPRD:01383(in vitro)  ViewAnalyzing