Regulatory Network in Protein Phosphorylation
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Substrate: PIP5K3

Description: FYVE finger-containing phosphoinositide kinase (EC (1-phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3-phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve)(p235).

Synonyms: KIAA0981, PIKFYVE

Ensembl ID: ENSG00000115020

UniprotKB/SwissProt: FYV1_HUMAN (Q9Y2I7)

Function: Supports the intracellular PIP pool and to a lesser extent, the PI 4,5-P(2) pool. It generates PIP from PI and, to a lesser extent, PI 4,5-P(2) from PI 4-P. There are indications that it phosphorylates the D-5 rather than the D-4 position. Has a role in endosome-related membrane trafficking (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Endosome membrane. Note=Mainly associated with membranes of the late endocytic pathway.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of PIP5K3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1PIP5K3FYV1_HUMANY46PFKSA Y SSFVN 16.37% Swiss-Prot 55.0 View   
2PIP5K3FYV1_HUMANY46PFKSA Y SSFVN 16.37% Phospho.ELM 7.0View   
3PIP5K3FYV1_HUMANS307RNRSA S ITNLS 31.06% Swiss-Prot 55.0 (Similarity)View   
4PIP5K3FYV1_HUMANS307RNRSA S ITNLS 31.06%AKT_group Phospho.ELM 7.0 ViewAnalyzing
5PIP5K3FYV1_HUMANY1155RMLAD Y RARGG 10.68% Swiss-Prot 55.0 View   
6PIP5K3FYV1_HUMANY1155RMLAD Y RARGG 10.68% Phospho.ELM 7.0View   
7PIP5K3FYV1_HUMANY1772GADSA Y YQVGQ 9.81% Swiss-Prot 55.0 View   
8PIP5K3FYV1_HUMANY1772GADSA Y YQVGQ 9.81% Phospho.ELM 7.0View