|Description: FYVE finger-containing phosphoinositide kinase (EC 22.214.171.124) (1-phosphatidylinositol-4-phosphate 5-kinase) (Phosphatidylinositol-3-phosphate 5-kinase type III) (PIP5K) (PtdIns(4)P-5-kinase) (PIKfyve)(p235).|
Synonyms: KIAA0981, PIKFYVE
Ensembl ID: ENSG00000115020
UniprotKB/SwissProt: FYV1_HUMAN (Q9Y2I7)
Function: Supports the intracellular PIP pool and to a lesser extent, the PI 4,5-P(2) pool. It generates PIP from PI and, to a lesser extent, PI 4,5-P(2) from PI 4-P. There are indications that it phosphorylates the D-5 rather than the D-4 position. Has a role in endosome-related membrane trafficking (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endosome membrane. Note=Mainly associated with membranes of the late endocytic pathway.