Regulatory Network in Protein Phosphorylation
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Substrate: RAC1

Description: Ras-related C3 botulinum toxin substrate 1 precursor (p21-Rac1) (Ras-like protein TC25) (Cell migration-inducing gene 5 protein).

Ensembl ID: ENSG00000136238

UniprotKB/SwissProt: RAC1_HUMAN (P63000)

Function: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP- dependent manner, suggesting that the insertion does not completely abolish effector interaction.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Lipid-anchor; Cytoplasmic side (By similarity). Melanosome. Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C- terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fra
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RAC1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RAC1RAC1_HUMANS71RLRPL S YPQTD 37.13%AKT1 HPRD:03627(in vitro;in vivo)  ViewAnalyzing
2RAC1RAC1_HUMANS71RLRPL S YPQTD 37.13%AKT_group Phospho.ELM 7.0 ViewAnalyzing