Regulatory Network in Protein Phosphorylation
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Substrate: RAF1

Description: RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf-1) (C-RAF) (cRaf).

Synonyms: RAF

Ensembl ID: ENSG00000132155

UniprotKB/SwissProt: RAF1_HUMAN (P04049)

Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from apoptosis mediated by STK3.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:
PDB:1C1Y
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of RAF1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1RAF1RAF1_HUMANS29GSSCI S PTIVQ 21.96% Phospho.ELM 7.0View   
2RAF1RAF1_HUMANS29GSSCI S PTIVQ 21.96%Erk2 HPRD:01265(in vitro;in vivo)  ViewAnalyzing
3RAF1RAF1_HUMANS43YQRRA S DDGKL 34.13% Swiss-Prot 55.0 View   
4RAF1RAF1_HUMANS43YQRRA S DDGKL 34.13%PKA_group Phospho.ELM 7.0 ViewAnalyzing
5RAF1RAF1_HUMANS43YQRRA S DDGKL 34.13%PKACa HPRD:01265(in vitro;in vivo)  ViewAnalyzing
6RAF1RAF1_HUMANS233SQHRY S TPHAF 35.10% Phospho.ELM 7.0View   
7RAF1RAF1_HUMANS233SQHRY S TPHAF 35.10%PKACa HPRD:01265(in vitro;in vivo)  ViewAnalyzing
8RAF1RAF1_HUMANS252SEGSL S QRQRS 25.64% Swiss-Prot 55.0 View   
9RAF1RAF1_HUMANS259RQRST S TPNVH 43.01%PKA_group Phospho.ELM 7.0 ViewAnalyzing
10RAF1RAF1_HUMANS259RQRST S TPNVH 43.01%AKT1 HPRD:01265(in vitro;in vivo)  ViewAnalyzing
11RAF1RAF1_HUMANS259RQRST S TPNVH 43.01%PKACa HPRD:01265(in vitro;in vivo)  ViewAnalyzing
12RAF1RAF1_HUMANS259RQRST S TPNVH 43.01%AKT_group Phospho.ELM 7.0 ViewAnalyzing
13RAF1RAF1_HUMANS259RQRST S TPNVH 43.01%AMPK_group Phospho.ELM 7.0 ViewAnalyzing
14RAF1RAF1_HUMANS259RQRST S TPNVH 43.01%PKC_group Swiss-Prot 55.0  ViewAnalyzing
15RAF1RAF1_HUMANT268VHMVS T TLPVD 22.42%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
16RAF1RAF1_HUMANT268VHMVS T TLPVD 22.42%RAF1 HPRD:01265(in vitro)  ViewAnalyzing
17RAF1RAF1_HUMANT269HMVST T LPVDS 22.89%KSR1 Phospho.ELM 7.0  ViewAnalyzing
18RAF1RAF1_HUMANT269HMVST T LPVDS 22.89% HPRD:01265(in vitro;in vivo)View   
19RAF1RAF1_HUMANS289HSESA S PSALS 28.77% Phospho.ELM 7.0View   
20RAF1RAF1_HUMANS289HSESA S PSALS 28.77%Erk2 HPRD:01265(in vitro;in vivo)  ViewAnalyzing
21RAF1RAF1_HUMANS294SPSAL S SSPNN 28.61% Swiss-Prot 55.0 View   
22RAF1RAF1_HUMANS294SPSAL S SSPNN 28.61% Phospho.ELM 7.0View   
23RAF1RAF1_HUMANS296SALSS S PNNLS 28.42% Phospho.ELM 7.0View   
24RAF1RAF1_HUMANS296SALSS S PNNLS 28.42%Erk2 HPRD:01265(in vitro;in vivo)  ViewAnalyzing
25RAF1RAF1_HUMANS301SPNNL S PTGWS 23.65%Erk2 HPRD:01265(in vitro;in vivo)  ViewAnalyzing
26RAF1RAF1_HUMANS301SPNNL S PTGWS 23.65% Swiss-Prot 55.0 View   
27RAF1RAF1_HUMANS301SPNNL S PTGWS 23.65% Phospho.ELM 7.0View   
28RAF1RAF1_HUMANS338RGQRD S SYYWE 23.56%PAK2 Swiss-Prot 55.0   ViewAnalyzing
29RAF1RAF1_HUMANS338RGQRD S SYYWE 23.56%PAK3 Swiss-Prot 55.0   ViewAnalyzing
30RAF1RAF1_HUMANS338RGQRD S SYYWE 23.56%PAK1 HPRD:01265(in vitro;in vivo)  ViewAnalyzing
31RAF1RAF1_HUMANS338RGQRD S SYYWE 23.56%PAK_group Phospho.ELM 7.0 ViewAnalyzing
32RAF1RAF1_HUMANS338RGQRD S SYYWE 23.56%PAK3 Phospho.ELM 7.0  ViewAnalyzing
33RAF1RAF1_HUMANS338RGQRD S SYYWE 23.56%PAK3 HPRD:01265(in vitro;in vivo)  ViewAnalyzing
34RAF1RAF1_HUMANS338RGQRD S SYYWE 23.56%PAK1 Phospho.ELM 7.0  ViewAnalyzing
35RAF1RAF1_HUMANS339GQRDS S YYWEI 26.91%PAK1 Phospho.ELM 7.0  ViewAnalyzing
36RAF1RAF1_HUMANS339GQRDS S YYWEI 26.91% HPRD:01265(in vivo)View   
37RAF1RAF1_HUMANY340QRDSS Y YWEIE 19.29% Phospho.ELM 7.0View   
38RAF1RAF1_HUMANY340QRDSS Y YWEIE 19.29%JAK2 HPRD:01265(in vitro;in vivo)  ViewAnalyzing
39RAF1RAF1_HUMANY341RDSSY Y WEIEA 9.86%Src Phospho.ELM 7.0  ViewAnalyzing
40RAF1RAF1_HUMANY341RDSSY Y WEIEA 9.86%JAK2 HPRD:01265(in vitro;in vivo)  ViewAnalyzing
41RAF1RAF1_HUMANY341RDSSY Y WEIEA 9.86%SRC HPRD:01265(in vitro;in vivo)  ViewAnalyzing
42RAF1RAF1_HUMANS471HRDMK S NNIFL 28.59% Phospho.ELM 7.0View   
43RAF1RAF1_HUMANT491DFGLA T VKSRW 33.24% HPRD:01265(in vitro;in vivo)View   
44RAF1RAF1_HUMANT491DFGLA T VKSRW 33.24% Phospho.ELM 7.0View   
45RAF1RAF1_HUMANS494LATVK S RWSGS 34.35% HPRD:01265(in vitro;in vivo)View   
46RAF1RAF1_HUMANS494LATVK S RWSGS 34.35% Phospho.ELM 7.0View   
47RAF1RAF1_HUMANS499SRWSG S QQVEQ 16.36%PKC_group Swiss-Prot 55.0  ViewAnalyzing
48RAF1RAF1_HUMANS499SRWSG S QQVEQ 16.36%PKC_group Phospho.ELM 7.0 ViewAnalyzing
49RAF1RAF1_HUMANS499SRWSG S QQVEQ 16.36%PKCa HPRD:01265(in vitro;in vivo)  ViewAnalyzing
50RAF1RAF1_HUMANS621INRSA S EPSLH 51.81%PKA_group Phospho.ELM 7.0 ViewAnalyzing
51RAF1RAF1_HUMANS621INRSA S EPSLH 51.81%PKACa HPRD:01265(in vitro;in vivo)  ViewAnalyzing
52RAF1RAF1_HUMANS621INRSA S EPSLH 51.81%RAF1 HPRD:01265(in vitro;in vivo)  ViewAnalyzing
53RAF1RAF1_HUMANS621INRSA S EPSLH 51.81% Swiss-Prot 55.0 View   
54RAF1RAF1_HUMANS621INRSA S EPSLH 51.81%AMPK_group Phospho.ELM 7.0 ViewAnalyzing
55RAF1RAF1_HUMANS621INRSA S EPSLH 51.81%AMPKa1 HPRD:01265(in vitro;in vivo)  ViewAnalyzing
56RAF1RAF1_HUMANS642CTLTT S PRLPV 11.64%Erk2 HPRD:01265(in vitro;in vivo)  ViewAnalyzing