|Description: SH2B adapter protein 2 (SH2 and PH domain-containing adapter proteinAPS) (Adapter protein with pleckstrin homology and Src homology 2domains).|
Ensembl ID: ENSG00000160999
UniprotKB/SwissProt: SH2B2_HUMAN (O14492)
Function: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.