Regulatory Network in Protein Phosphorylation
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Substrate: SH2B2

Description: SH2B adapter protein 2 (SH2 and PH domain-containing adapter proteinAPS) (Adapter protein with pleckstrin homology and Src homology 2domains).

Synonyms: APS

Ensembl ID: ENSG00000160999

UniprotKB/SwissProt: SH2B2_HUMAN (O14492)

Function: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell membrane. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region.
PDB:1Q2H
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of SH2B2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1SH2B2SH2B2_HUMANS598RSRSN S AERLL 32.52%AKT1 HPRD:16097(in vitro;in vivo)  ViewAnalyzing
2SH2B2SH2B2_HUMANY629AVENQ Y SFY 16.60% Swiss-Prot 55.0 View