Regulatory Network in Protein Phosphorylation
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Substrate: TERT

Description: Telomerase reverse transcriptase (EC 2.7.7.49) (Telomerase catalyticsubunit) (HEST2) (Telomerase-associated protein 2) (TP2).

Synonyms: EST2, TCS1, TRT

Ensembl ID: ENSG00000164362

UniprotKB/SwissProt: TERT_HUMAN (O14746)

Function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.
PDB:2BCK
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TERT

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TERTTERT_HUMANS227RRRGG S ASRSL 26.37%AKT_group Phospho.ELM 7.0 ViewAnalyzing
2TERTTERT_HUMANS227RRRGG S ASRSL 26.37%AKT1 HPRD:01754(in vitro;in vivo)  ViewAnalyzing
3TERTTERT_HUMANY707PPPEL Y FVKVD 12.50%SRC HPRD:01754(in vivo)  ViewAnalyzing
4TERTTERT_HUMANY707PPPEL Y FVKVD 12.50%Src Phospho.ELM 7.0  ViewAnalyzing
5TERTTERT_HUMANS797IEQSS S LNEAS 40.22% Phospho.ELM 7.0View   
6TERTTERT_HUMANS824RIRGK S YVQCQ 33.10%AKT_group Phospho.ELM 7.0 ViewAnalyzing
7TERTTERT_HUMANS824RIRGK S YVQCQ 33.10%AKT1 HPRD:01754(in vitro;in vivo)  ViewAnalyzing
8TERTTERT_HUMANT1101LRTAQ T QLSRK 29.07% HPRD:01754(in vivo)View   
9TERTTERT_HUMANT1113PGTTL T ALEAA 27.40% Phospho.ELM 7.0View   
10TERTTERT_HUMANT1113PGTTL T ALEAA 27.40% Swiss-Prot 55.0 View   
11TERTTERT_HUMANS1125NPALP S DFKTI 57.43% HPRD:01754(in vivo)View   
12TERTTERT_HUMANS1125NPALP S DFKTI 57.43% Phospho.ELM 7.0View   
13TERTTERT_HUMANS1125NPALP S DFKTI 57.43% Swiss-Prot 55.0 View