|Description: Tuberin (Tuberous sclerosis 2 protein).|
Ensembl ID: ENSG00000103197
UniprotKB/SwissProt: TSC2_HUMAN (P49815)
Function: Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth. Mutations in TSC2 leads to constitutive activation of RAP1A in tumors.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.