Regulatory Network in Protein Phosphorylation
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Substrate: TSC2

Description: Tuberin (Tuberous sclerosis 2 protein).

Synonyms: TSC4

Ensembl ID: ENSG00000103197

UniprotKB/SwissProt: TSC2_HUMAN (P49815)

Function: Implicated as a tumor suppressor. May have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth. Mutations in TSC2 leads to constitutive activation of RAP1A in tumors.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of TSC2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1TSC2TSC2_HUMANS540MARSL S PPPEL 36.29%Erk2 HPRD:01850(in vitro;in vivo)  ViewAnalyzing
2TSC2TSC2_HUMANS540MARSL S PPPEL 36.29% Phospho.ELM 7.0View   
3TSC2TSC2_HUMANS664TSGPL S PPTGP 31.78%Erk2 HPRD:01850(in vitro;in vivo)  ViewAnalyzing
4TSC2TSC2_HUMANS664TSGPL S PPTGP 31.78%Erk2(MAPK1) Phospho.ELM 7.0 ViewAnalyzing
5TSC2TSC2_HUMANS939RARST S LNERP 30.37%AKT_group Phospho.ELM 7.0 ViewAnalyzing
6TSC2TSC2_HUMANS939RARST S LNERP 30.37%AKT1 HPRD:01850(in vivo)  ViewAnalyzing
7TSC2TSC2_HUMANS939RARST S LNERP 30.37%AKT1 HPRD:01850(in vitro)  ViewAnalyzing
8TSC2TSC2_HUMANS981RCRSI S VSEHV 22.34% Phospho.ELM 7.0View   
9TSC2TSC2_HUMANS981RCRSI S VSEHV 22.34% Swiss-Prot 55.0 (Similarity)View   
10TSC2TSC2_HUMANS1254LYKSL S VPAAS 32.90%MAPKAPK2 HPRD:01850(in vitro)  ViewAnalyzing
11TSC2TSC2_HUMANS1254LYKSL S VPAAS 32.90%MAPKAPK2 Phospho.ELM 7.0  ViewAnalyzing
12TSC2TSC2_HUMANS1364IERVV S SEGGR 21.58% Swiss-Prot 55.0 (Similarity)View   
13TSC2TSC2_HUMANS1387LSKSS S SPELQ 57.93% Swiss-Prot 55.0 View   
14TSC2TSC2_HUMANS1387LSKSS S SPELQ 57.93% Phospho.ELM 7.0View   
15TSC2TSC2_HUMANS1411DVGRL S PEVKA 20.04% Phospho.ELM 7.0View   
16TSC2TSC2_HUMANS1411DVGRL S PEVKA 20.04% Swiss-Prot 55.0 View   
17TSC2TSC2_HUMANS1418EVKAR S QSGTL 33.29% Phospho.ELM 7.0View   
18TSC2TSC2_HUMANS1418EVKAR S QSGTL 33.29% Swiss-Prot 55.0 View   
19TSC2TSC2_HUMANS1420KARSQ S GTLDG 34.68% Phospho.ELM 7.0View   
20TSC2TSC2_HUMANS1420KARSQ S GTLDG 34.68% Swiss-Prot 55.0 View   
21TSC2TSC2_HUMANY1461LRPRG Y TISDS 11.37% HPRD:01850(in vitro)View   
22TSC2TSC2_HUMANT1462RPRGY T ISDSA 19.48%AKT1 HPRD:01850(in vitro;in vivo)  ViewAnalyzing
23TSC2TSC2_HUMANT1462RPRGY T ISDSA 19.48%AKT_group Phospho.ELM 7.0 ViewAnalyzing
24TSC2TSC2_HUMANY1571HGSYR Y TEFLT 11.46% HPRD:01850(in vitro;in vivo)View   
25TSC2TSC2_HUMANY1571HGSYR Y TEFLT 11.46% Phospho.ELM 7.0View   
26TSC2TSC2_HUMANY1571HGSYR Y TEFLT 11.46% HPRD:01850(in vitro)View   
27TSC2TSC2_HUMANS1798RKRLI S SVEDF 32.68% Swiss-Prot 55.0 View   
28TSC2TSC2_HUMANS1798RKRLI S SVEDF 32.68%RSK_group Phospho.ELM 7.0 ViewAnalyzing