Regulatory Network in Protein Phosphorylation
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Substrate: WNK1

Description: Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Protein kinasewith no lysine 1) (Protein kinase, lysine-deficient 1) (Kinasedeficient protein) (Erythrocyte 65 kDa protein) (p65).

Synonyms: KDP, KIAA0344, PRKWNK1

Ensembl ID: ENSG00000060237

UniprotKB/SwissProt: WNK1_HUMAN (Q9H4A3)

Function: Controls sodium and chloride ion transport by inhibiting the activity of WNK4, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of WNK1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1WNK1WNK1_HUMANT60RRRRH T MDKDS 25.83%AKT_group Phospho.ELM 7.0 ViewAnalyzing
2WNK1WNK1_HUMANS167KDRPV S QPSLV 38.77% Swiss-Prot 55.0 View   
3WNK1WNK1_HUMANS174PSLVG S KEEPP 29.43% Swiss-Prot 55.0 View   
4WNK1WNK1_HUMANS378TLKRA S FAKSV 29.75%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
5WNK1WNK1_HUMANS378TLKRA S FAKSV 29.75% Phospho.ELM 7.0View   
6WNK1WNK1_HUMANS382ASFAK S VIGTP 18.61%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
7WNK1WNK1_HUMANS1261RRFIV S PVPES 18.50% Swiss-Prot 55.0 View   
8WNK1WNK1_HUMANS1978EGPVA S PPFMD 33.08% Swiss-Prot 55.0 View   
9WNK1WNK1_HUMANS2002EKPEL S EPSHL 45.88% Phospho.ELM 7.0View   
10WNK1WNK1_HUMANS2002EKPEL S EPSHL 45.88% Swiss-Prot 55.0 View   
11WNK1WNK1_HUMANS2011HLNGP S SDPEA 49.09% Swiss-Prot 55.0 View   
12WNK1WNK1_HUMANS2011HLNGP S SDPEA 49.09% Phospho.ELM 7.0View   
13WNK1WNK1_HUMANS2012LNGPS S DPEAA 61.39% Swiss-Prot 55.0 View   
14WNK1WNK1_HUMANS2012LNGPS S DPEAA 61.39% Phospho.ELM 7.0View   
15WNK1WNK1_HUMANS2032SGSPH S PHQLS 27.71% Phospho.ELM 7.0View   
16WNK1WNK1_HUMANS2032SGSPH S PHQLS 27.71% Swiss-Prot 55.0 View   
17WNK1WNK1_HUMANS2038PHQLS S KSLPS 34.55% Swiss-Prot 55.0 View