|Description: Serine/threonine-protein kinase WNK1 (EC 184.108.40.206) (Protein kinasewith no lysine 1) (Protein kinase, lysine-deficient 1) (Kinasedeficient protein) (Erythrocyte 65 kDa protein) (p65).|
Synonyms: KDP, KIAA0344, PRKWNK1
Ensembl ID: ENSG00000060237
UniprotKB/SwissProt: WNK1_HUMAN (Q9H4A3)
Function: Controls sodium and chloride ion transport by inhibiting the activity of WNK4, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide- sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.