Regulatory Network in Protein Phosphorylation
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Substrate: YBX1

Description: Nuclease-sensitive element-binding protein 1 (Y-box-binding protein 1)(Y-box transcription factor) (YB-1) (CCAAT-binding transcriptionfactor I subunit A) (CBF-A) (Enhancer factor I subunit A) (EFI-A)(DNA-binding protein B) (DBPB).

Synonyms: NSEP1, YB1

Ensembl ID: ENSG00000065978

UniprotKB/SwissProt: YBOX1_HUMAN (P67809)

Function: Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Binds to promoters that contain a Y-box (5'- CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus.
PDB:1H95
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of YBX1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1YBX1YBOX1_HUMANS102RKYLR S VGDGE 28.05%AKT1 HPRD:01095(in vitro;in vivo)  ViewAnalyzing
2YBX1YBOX1_HUMANS102RKYLR S VGDGE 28.05% Phospho.ELM 7.0View   
3YBX1YBOX1_HUMANS102RKYLR S VGDGE 28.05%AKT1(PKB) Swiss-Prot 55.0  ViewAnalyzing
4YBX1YBOX1_HUMANY162NYQQN Y QNSES 12.53% Phospho.ELM 7.0View   
5YBX1YBOX1_HUMANY162NYQQN Y QNSES 12.53% Swiss-Prot 55.0 View   
6YBX1YBOX1_HUMANS165QNYQN S ESGEK 20.02% Phospho.ELM 7.0View   
7YBX1YBOX1_HUMANS165QNYQN S ESGEK 20.02% Swiss-Prot 55.0 View   
8YBX1YBOX1_HUMANS167YQNSE S GEKNE 52.66% Swiss-Prot 55.0 View   
9YBX1YBOX1_HUMANS174EKNEG S ESAPE 23.38% Swiss-Prot 55.0 View   
10YBX1YBOX1_HUMANS174EKNEG S ESAPE 23.38% Phospho.ELM 7.0View   
11YBX1YBOX1_HUMANS176NEGSE S APEGQ 51.31% Swiss-Prot 55.0 View   
12YBX1YBOX1_HUMANS176NEGSE S APEGQ 51.31% Phospho.ELM 7.0View   
13YBX1YBOX1_HUMANS314PAENS S APEAE 60.47% Swiss-Prot 55.0 View   
14YBX1YBOX1_HUMANS314PAENS S APEAE 60.47% Phospho.ELM 7.0View