|Description: Nuclease-sensitive element-binding protein 1 (Y-box-binding protein 1)(Y-box transcription factor) (YB-1) (CCAAT-binding transcriptionfactor I subunit A) (CBF-A) (Enhancer factor I subunit A) (EFI-A)(DNA-binding protein B) (DBPB).|
Synonyms: NSEP1, YB1
Ensembl ID: ENSG00000065978
UniprotKB/SwissProt: YBOX1_HUMAN (P67809)
Function: Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Binds to promoters that contain a Y-box (5'- CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Shuttles between nucleus and cytoplasm. Predominantly cytoplasmic in proliferating cells. Cytotoxic stress and DNA damage enhance translocation to the nucleus.