Regulatory Network in Protein Phosphorylation
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Substrate: YWHAZ

Description: 14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1)(KCIP-1).

Ensembl ID: ENSG00000164924

UniprotKB/SwissProt: 1433Z_HUMAN (P63104)

Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
PDB:1IB1
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of YWHAZ

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1YWHAZ1433Z_HUMANS58GARRS S WRVVS 19.65%PKACa HPRD:03183(in vitro)  ViewAnalyzing
2YWHAZ1433Z_HUMANS58GARRS S WRVVS 19.65%MAPKAPK2 HPRD:03183(in vitro;in vivo)  ViewAnalyzing
3YWHAZ1433Z_HUMANS58GARRS S WRVVS 19.65%PKCd HPRD:03183(in vivo)  ViewAnalyzing
4YWHAZ1433Z_HUMANS58GARRS S WRVVS 19.65%AKT1 HPRD:03183(in vitro;in vivo)  ViewAnalyzing
5YWHAZ1433Z_HUMANS58GARRS S WRVVS 19.65%AKT_group Phospho.ELM 7.0 ViewAnalyzing
6YWHAZ1433Z_HUMANS58GARRS S WRVVS 19.65%PKA_group Phospho.ELM 7.0 ViewAnalyzing
7YWHAZ1433Z_HUMANS184YEILN S PEKAC 30.87% Swiss-Prot 55.0 (Similarity)View   
8YWHAZ1433Z_HUMANS184YEILN S PEKAC 30.87%AKT1 HPRD:03183(in vivo)  ViewAnalyzing
9YWHAZ1433Z_HUMANS184YEILN S PEKAC 30.87%JNK1(MAPK8) Phospho.ELM 7.0 ViewAnalyzing
10YWHAZ1433Z_HUMANS184YEILN S PEKAC 30.87%JNK1 HPRD:03183(in vivo)  ViewAnalyzing
11YWHAZ1433Z_HUMANT232LWTSD T QGDEA 33.93% Swiss-Prot 55.0 View   
12YWHAZ1433Z_HUMANT232LWTSD T QGDEA 33.93%CK1a HPRD:03183(in vivo)  ViewAnalyzing
13YWHAZ1433Z_HUMANT232LWTSD T QGDEA 33.93%CK1a(CK1 alpha) Phospho.ELM 7.0 ViewAnalyzing