Regulatory Network in Protein Phosphorylation
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Substrate: ACO1

Description: Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron regulatoryprotein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase)(EC 4.2.1.3) (Citrate hydro-lyase) (Aconitase).

Synonyms: IREB1

Ensembl ID: ENSG00000122729

UniprotKB/SwissProt: IREB1_HUMAN (P21399)

Function: Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. This protein also expresses aconitase activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.
PDB:2B3X
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ACO1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ACO1IREB1_HUMANS138NRRAD S LQKNQ 31.54%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
2ACO1IREB1_HUMANS138NRRAD S LQKNQ 31.54% HPRD:00013(in vitro)View   
3ACO1IREB1_HUMANS711FNSYG S RRGND 15.57%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
4ACO1IREB1_HUMANS711FNSYG S RRGND 15.57% HPRD:00013(in vitro)View