|Description: Iron-responsive element-binding protein 1 (IRE-BP 1) (Iron regulatoryprotein 1) (IRP1) (Ferritin repressor protein) (Aconitate hydratase)(EC 188.8.131.52) (Citrate hydro-lyase) (Aconitase).|
Ensembl ID: ENSG00000122729
UniprotKB/SwissProt: IREB1_HUMAN (P21399)
Function: Binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. This protein also expresses aconitase activity.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.