Regulatory Network in Protein Phosphorylation
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Substrate: ADD1

Description: Alpha-adducin (Erythrocyte adducin subunit alpha).

Synonyms: ADDA

Ensembl ID: ENSG00000087274

UniprotKB/SwissProt: ADDA_HUMAN (P35611)

Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ADD1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ADD1ADDA_HUMANS5-MNGD S RAAVV 25.80%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
2ADD1ADDA_HUMANS5-MNGD S RAAVV 25.80%PKCz(PKC zeta) Phospho.ELM 7.0 ViewAnalyzing
3ADD1ADDA_HUMANS12AAVVT S PPPTT 24.65% Swiss-Prot 55.0 (Similarity)View   
4ADD1ADDA_HUMANS59QKKRV S MILQS 12.25%PKA_group Phospho.ELM 7.0 ViewAnalyzing
5ADD1ADDA_HUMANS59QKKRV S MILQS 12.25%PKA_group Swiss-Prot 55.0  ViewAnalyzing
6ADD1ADDA_HUMANS353KYKAK S RSPGS 42.73% Swiss-Prot 55.0 View   
7ADD1ADDA_HUMANS355KAKSR S PGSPV 40.48% Swiss-Prot 55.0 View   
8ADD1ADDA_HUMANS355KAKSR S PGSPV 40.48% Phospho.ELM 7.0View   
9ADD1ADDA_HUMANS358SRSPG S PVGEG 21.57% Swiss-Prot 55.0 View   
10ADD1ADDA_HUMANS358SRSPG S PVGEG 21.57% HPRD:00036(in vivo)View   
11ADD1ADDA_HUMANS358SRSPG S PVGEG 21.57% Phospho.ELM 7.0View   
12ADD1ADDA_HUMANS408KSKKY S DVEVP 44.02%PKA_group Phospho.ELM 7.0 ViewAnalyzing
13ADD1ADDA_HUMANS408KSKKY S DVEVP 44.02%PKA_group Swiss-Prot 55.0  ViewAnalyzing
14ADD1ADDA_HUMANS408KSKKY S DVEVP 44.02%PKACa HPRD:00036(in vitro)  ViewAnalyzing
15ADD1ADDA_HUMANS436SPLRH S FQKQQ 23.96%PKA_group Phospho.ELM 7.0 ViewAnalyzing
16ADD1ADDA_HUMANS436SPLRH S FQKQQ 23.96%PKA_group Swiss-Prot 55.0  ViewAnalyzing
17ADD1ADDA_HUMANS436SPLRH S FQKQQ 23.96%PKACa HPRD:00036(in vitro)  ViewAnalyzing
18ADD1ADDA_HUMANT445QQREK T RWLNS 23.48%ROCK_group Phospho.ELM 7.0 ViewAnalyzing
19ADD1ADDA_HUMANT445QQREK T RWLNS 23.48%ROCK1 HPRD:00036(in vitro;in vivo)  ViewAnalyzing
20ADD1ADDA_HUMANT445QQREK T RWLNS 23.48%ROCK1 HPRD:00036(in vivo)  ViewAnalyzing
21ADD1ADDA_HUMANT445QQREK T RWLNS 23.48%ROCK1 Phospho.ELM 7.0  ViewAnalyzing
22ADD1ADDA_HUMANT445QQREK T RWLNS 23.48%ROCK1 Swiss-Prot 55.0   ViewAnalyzing
23ADD1ADDA_HUMANS465GQNGS S PKSKT 37.43% Phospho.ELM 7.0View   
24ADD1ADDA_HUMANS465GQNGS S PKSKT 37.43% HPRD:00036(in vivo)View   
25ADD1ADDA_HUMANS465GQNGS S PKSKT 37.43% Swiss-Prot 55.0 View   
26ADD1ADDA_HUMANT480EDGHR T STSAV 30.59%ROCK1 HPRD:00036(in vivo)  ViewAnalyzing
27ADD1ADDA_HUMANT480EDGHR T STSAV 30.59%ROCK_group Phospho.ELM 7.0 ViewAnalyzing
28ADD1ADDA_HUMANT480EDGHR T STSAV 30.59%ROCK1 HPRD:00036(in vitro;in vivo)  ViewAnalyzing
29ADD1ADDA_HUMANT480EDGHR T STSAV 30.59%ROCK1 Swiss-Prot 55.0   ViewAnalyzing
30ADD1ADDA_HUMANS481DGHRT S TSAVP 21.96%PKA_group Swiss-Prot 55.0  ViewAnalyzing
31ADD1ADDA_HUMANS481DGHRT S TSAVP 21.96%PKA_group Phospho.ELM 7.0 ViewAnalyzing
32ADD1ADDA_HUMANS483HRTST S AVPNL 27.34% Swiss-Prot 55.0 (Similarity)View   
33ADD1ADDA_HUMANS586RKQKG S EENLD 49.09% Swiss-Prot 55.0 (Similarity)View   
34ADD1ADDA_HUMANS600EQKEK S PPDQP 42.64% Phospho.ELM 7.0View   
35ADD1ADDA_HUMANT614HPPPS T PIKLE 34.50% Swiss-Prot 55.0 (Similarity)View   
36ADD1ADDA_HUMANS695EEAAP S AVEEG 39.97%PKCd HPRD:00036(in vitro;in vivo)  ViewAnalyzing
37ADD1ADDA_HUMANS707AADPG S DGSPG 44.16% Swiss-Prot 55.0 View   
38ADD1ADDA_HUMANS710PGSDG S PGKSP 35.15% Swiss-Prot 55.0 View   
39ADD1ADDA_HUMANS716PGKSP S KKKKK 65.29%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
40ADD1ADDA_HUMANS716PGKSP S KKKKK 65.29%PKC_group Swiss-Prot 55.0  ViewAnalyzing
41ADD1ADDA_HUMANS726KFRTP S FLKKS 42.47%PKA_group Swiss-Prot 55.0  ViewAnalyzing
42ADD1ADDA_HUMANS726KFRTP S FLKKS 42.47%PKC_group Swiss-Prot 55.0  ViewAnalyzing
43ADD1ADDA_HUMANS726KFRTP S FLKKS 42.47%PKC_group Phospho.ELM 7.0 ViewAnalyzing
44ADD1ADDA_HUMANS726KFRTP S FLKKS 42.47%PKCd HPRD:00036(in vitro;in vivo)  ViewAnalyzing
45ADD1ADDA_HUMANS726KFRTP S FLKKS 42.47%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
46ADD1ADDA_HUMANS726KFRTP S FLKKS 42.47%PKCz(PKC zeta) Phospho.ELM 7.0 ViewAnalyzing