Regulatory Network in Protein Phosphorylation
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Substrate: ADRB2

Description: Beta-2 adrenergic receptor (Beta-2 adrenoceptor) (Beta-2adrenoreceptor).

Synonyms: ADRB2R, B2AR

Ensembl ID: ENSG00000169252

UniprotKB/SwissProt: ADRB2_HUMAN (P07550)

Function: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ADRB2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ADRB2ADRB2_HUMANY132IAVDR Y FAITS 7.90%IGF1R Phospho.ELM 7.0  ViewAnalyzing
2ADRB2ADRB2_HUMANY132IAVDR Y FAITS 7.90%INSR HPRD:00187(in vivo)  ViewAnalyzing
3ADRB2ADRB2_HUMANY141TSPFK Y QSLLT 12.06%INSR HPRD:00187(in vivo)  ViewAnalyzing
4ADRB2ADRB2_HUMANY141TSPFK Y QSLLT 12.06%IGF1R Phospho.ELM 7.0  ViewAnalyzing
5ADRB2ADRB2_HUMANS246HVQNL S QVEQD 39.46% Swiss-Prot 55.0 View   
6ADRB2ADRB2_HUMANS261HGLRR S SKFCL 31.29%PKA_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
7ADRB2ADRB2_HUMANS261HGLRR S SKFCL 31.29%PKCd HPRD:00187(in vivo)  ViewAnalyzing
8ADRB2ADRB2_HUMANS262GLRRS S KFCLK 28.12%PKA_group Phospho.ELM 7.0 ViewAnalyzing
9ADRB2ADRB2_HUMANS262GLRRS S KFCLK 28.12%PKCd HPRD:00187(in vivo)  ViewAnalyzing
10ADRB2ADRB2_HUMANS262GLRRS S KFCLK 28.12%PKA_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
11ADRB2ADRB2_HUMANY326FNPLI Y CRSPD 6.90% Phospho.ELM 7.0View   
12ADRB2ADRB2_HUMANY326FNPLI Y CRSPD 6.90% HPRD:00187(in vitro)View   
13ADRB2ADRB2_HUMANS345LCLRR S SLKAY 33.32%PKA_group Swiss-Prot 55.0  ViewAnalyzing
14ADRB2ADRB2_HUMANS345LCLRR S SLKAY 33.32%PKCd HPRD:00187(in vivo)  ViewAnalyzing
15ADRB2ADRB2_HUMANS345LCLRR S SLKAY 33.32%PKA_group Phospho.ELM 7.0 ViewAnalyzing
16ADRB2ADRB2_HUMANS346CLRRS S LKAYG 31.88%AKT_group Phospho.ELM 7.0 ViewAnalyzing
17ADRB2ADRB2_HUMANS346CLRRS S LKAYG 31.88%PKA_group Swiss-Prot 55.0  ViewAnalyzing
18ADRB2ADRB2_HUMANS346CLRRS S LKAYG 31.88%PKCd HPRD:00187(in vivo)  ViewAnalyzing
19ADRB2ADRB2_HUMANS346CLRRS S LKAYG 31.88%PKA_group Phospho.ELM 7.0 ViewAnalyzing
20ADRB2ADRB2_HUMANY350SSLKA Y GNGYS 14.99%INSR HPRD:00187(in vivo)  ViewAnalyzing
21ADRB2ADRB2_HUMANY354AYGNG Y SSNGN 16.96%INSR HPRD:00187(in vivo)  ViewAnalyzing
22ADRB2ADRB2_HUMANS355YGNGY S SNGNT 20.80%GRK_group Phospho.ELM 7.0 ViewAnalyzing
23ADRB2ADRB2_HUMANS355YGNGY S SNGNT 20.80%BARK_group  Swiss-Prot 55.0 (Probable) ViewAnalyzing
24ADRB2ADRB2_HUMANS356GNGYS S NGNTG 40.03%BARK_group  Swiss-Prot 55.0 (Probable) ViewAnalyzing
25ADRB2ADRB2_HUMANS356GNGYS S NGNTG 40.03%GRK_group Phospho.ELM 7.0 ViewAnalyzing
26ADRB2ADRB2_HUMANS364NTGEQ S GYHVE 36.70% HPRD:00187(in vivo)View   
27ADRB2ADRB2_HUMANT384EDLPG T EDFVG 30.37%BARK1(GRK2) Phospho.ELM 7.0 ViewAnalyzing
28ADRB2ADRB2_HUMANT384EDLPG T EDFVG 30.37%GPRK5(GRK5) Phospho.ELM 7.0 ViewAnalyzing
29ADRB2ADRB2_HUMANT384EDLPG T EDFVG 30.37%GPRK5 HPRD:00187(in vitro)  ViewAnalyzing
30ADRB2ADRB2_HUMANT393VGHQG T VPSDN 23.75%GPRK5(GRK5) Phospho.ELM 7.0 ViewAnalyzing
31ADRB2ADRB2_HUMANT393VGHQG T VPSDN 23.75%GPRK5 HPRD:00187(in vitro)  ViewAnalyzing
32ADRB2ADRB2_HUMANS396QGTVP S DNIDS 38.66%GPRK5 HPRD:00187(in vitro)  ViewAnalyzing
33ADRB2ADRB2_HUMANS396QGTVP S DNIDS 38.66%BARK1(GRK2) Phospho.ELM 7.0 ViewAnalyzing
34ADRB2ADRB2_HUMANS396QGTVP S DNIDS 38.66%GPRK5(GRK5) Phospho.ELM 7.0 ViewAnalyzing
35ADRB2ADRB2_HUMANS401SDNID S QGRNC 30.64%GPRK5 HPRD:00187(in vitro)  ViewAnalyzing
36ADRB2ADRB2_HUMANS401SDNID S QGRNC 30.64%BARK1(GRK2) Phospho.ELM 7.0 ViewAnalyzing
37ADRB2ADRB2_HUMANS401SDNID S QGRNC 30.64%GPRK5(GRK5) Phospho.ELM 7.0 ViewAnalyzing
38ADRB2ADRB2_HUMANS407QGRNC S TNDSL 33.52%BARK1(GRK2) Phospho.ELM 7.0 ViewAnalyzing
39ADRB2ADRB2_HUMANS407QGRNC S TNDSL 33.52%GPRK5 HPRD:00187(in vitro)  ViewAnalyzing
40ADRB2ADRB2_HUMANS407QGRNC S TNDSL 33.52%GPRK5(GRK5) Phospho.ELM 7.0 ViewAnalyzing
41ADRB2ADRB2_HUMANS411CSTND S LL 33.37%GPRK5(GRK5) Phospho.ELM 7.0 ViewAnalyzing
42ADRB2ADRB2_HUMANS411CSTND S LL 33.37%GPRK5 HPRD:00187(in vitro)  ViewAnalyzing