Regulatory Network in Protein Phosphorylation
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Substrate: AKT3

Description: RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-gamma)(Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2).

Synonyms: PKBG

Ensembl ID: ENSG00000117020

UniprotKB/SwissProt: AKT3_HUMAN (Q9Y243)

Function: IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of AKT3

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1AKT3AKT3_HUMANS120ERMNC S PTSQI 26.63% Swiss-Prot 55.0 View   
2AKT3AKT3_HUMANS120ERMNC S PTSQI 26.63%PDHK1 HPRD:06441(in vitro)  ViewAnalyzing
3AKT3AKT3_HUMANS120ERMNC S PTSQI 26.63% Phospho.ELM 7.0View   
4AKT3AKT3_HUMANS123NCSPT S QIDNI 28.64% Swiss-Prot 55.0 View   
5AKT3AKT3_HUMANT305AATMK T FCGTP 17.21%PDK1 Swiss-Prot 55.0   ViewAnalyzing
6AKT3AKT3_HUMANT305AATMK T FCGTP 17.21%PDK1 HPRD:06441(in vitro;in vivo)  ViewAnalyzing
7AKT3AKT3_HUMANT305AATMK T FCGTP 17.21%PKCz HPRD:06441(in vivo)  ViewAnalyzing
8AKT3AKT3_HUMANT305AATMK T FCGTP 17.21%PDK1 Phospho.ELM 7.0  ViewAnalyzing
9AKT3AKT3_HUMANT447QTITI T PPEKY 24.92% Phospho.ELM 7.0View   
10AKT3AKT3_HUMANS472HFPQF S YSASG 16.96%PKCd HPRD:06441(in vivo)  ViewAnalyzing
11AKT3AKT3_HUMANS472HFPQF S YSASG 16.96% Phospho.ELM 7.0View   
12AKT3AKT3_HUMANS472HFPQF S YSASG 16.96% Swiss-Prot 55.0 (Similarity)View   
13AKT3AKT3_HUMANS472HFPQF S YSASG 16.96% HPRD:06441(in vivo)View