Regulatory Network in Protein Phosphorylation
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Substrate: ANXA2

Description: Annexin A2 (Annexin-2) (Annexin II) (Lipocortin II) (Calpactin I heavychain) (Chromobindin-8) (p36) (Protein I) (Placental anticoagulantprotein IV) (PAP-IV).

Synonyms: ANX2, ANX2L4, CAL1H, LPC2D

Ensembl ID: ENSG00000182718

UniprotKB/SwissProt: ANXA2_HUMAN (P07355)

Function: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the c
PDB:1W7B
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ANXA2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ANXA2ANXA2_HUMANS2----M S TVHEI 38.85%PKCb HPRD:01061(in vitro;in vivo)  ViewAnalyzing
2ANXA2ANXA2_HUMANT3---MS T VHEIL 25.28% Phospho.ELM 7.0View   
3ANXA2ANXA2_HUMANS12ILCKL S LEGDH 15.18% Phospho.ELM 7.0View   
4ANXA2ANXA2_HUMANS18LEGDH S TPPSA 47.55% Swiss-Prot 55.0 View   
5ANXA2ANXA2_HUMANS18LEGDH S TPPSA 47.55% Phospho.ELM 7.0View   
6ANXA2ANXA2_HUMANS18LEGDH S TPPSA 47.55% HPRD:01061(in vivo)View   
7ANXA2ANXA2_HUMANT19EGDHS T PPSAY 35.48% Swiss-Prot 55.0 View   
8ANXA2ANXA2_HUMANT19EGDHS T PPSAY 35.48% Phospho.ELM 7.0View   
9ANXA2ANXA2_HUMANY24TPPSA Y GSVKA 17.80%Src Phospho.ELM 7.0  ViewAnalyzing
10ANXA2ANXA2_HUMANY24TPPSA Y GSVKA 17.80% HPRD:01061(in vitro)View   
11ANXA2ANXA2_HUMANY24TPPSA Y GSVKA 17.80%SRC Swiss-Prot 55.0   ViewAnalyzing
12ANXA2ANXA2_HUMANS26PSAYG S VKAYT 14.04%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
13ANXA2ANXA2_HUMANS26PSAYG S VKAYT 14.04%PKCa HPRD:01061(in vitro;in vivo)  ViewAnalyzing
14ANXA2ANXA2_HUMANS26PSAYG S VKAYT 14.04%PKC_group Swiss-Prot 55.0  ViewAnalyzing
15ANXA2ANXA2_HUMANS26PSAYG S VKAYT 14.04%PKC_group Phospho.ELM 7.0 ViewAnalyzing
16ANXA2ANXA2_HUMANY30GSVKA Y TNFDA 9.12% Swiss-Prot 55.0 View   
17ANXA2ANXA2_HUMANY30GSVKA Y TNFDA 9.12% Phospho.ELM 7.0View   
18ANXA2ANXA2_HUMANY30GSVKA Y TNFDA 9.12% HPRD:01061(in vivo)View