|Description: Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (Hepatic lectinH2).|
Ensembl ID: ENSG00000161944
UniprotKB/SwissProt: ASGR2_HUMAN (P07307)
Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Single-pass type II membrane protein.