Regulatory Network in Protein Phosphorylation
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Substrate: ASGR2

Description: Asialoglycoprotein receptor 2 (ASGP-R 2) (ASGPR 2) (Hepatic lectinH2).

Ensembl ID: ENSG00000161944

UniprotKB/SwissProt: ASGR2_HUMAN (P07307)

Function: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type II membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ASGR2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ASGR2ASGR2_HUMANS12DIQQL S SEEND 31.22%PKC_group Phospho.ELM 7.0 ViewAnalyzing
2ASGR2ASGR2_HUMANS12DIQQL S SEEND 31.22% HPRD:00152(in vivo)View   
3ASGR2ASGR2_HUMANS13IQQLS S EENDH 58.48% Swiss-Prot 55.0 (Similarity)View