Regulatory Network in Protein Phosphorylation
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Substrate: ATP1A1

Description: Sodium/potassium-transporting ATPase subunit alpha-1 precursor(EC 3.6.3.9) (Sodium pump subunit alpha-1) (Na(+)/K(+) ATPase alpha-1subunit).

Ensembl ID: ENSG00000163399

UniprotKB/SwissProt: AT1A1_HUMAN (P05023)

Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ATP1A1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ATP1A1AT1A1_HUMANY10VGRDK Y EPAAV 31.28% HPRD:01662(in vitro)View   
2ATP1A1AT1A1_HUMANY10VGRDK Y EPAAV 31.28% Swiss-Prot 55.0 (Similarity)View   
3ATP1A1AT1A1_HUMANS16EPAAV S EQGDK 21.34% HPRD:01662(in vitro)View   
4ATP1A1AT1A1_HUMANS16EPAAV S EQGDK 21.34%PKC_group  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
5ATP1A1AT1A1_HUMANS47DDHKL S LDELH 38.28% Swiss-Prot 55.0 (Similarity)View   
6ATP1A1AT1A1_HUMANS217KVDNS S LTGES 35.88% Swiss-Prot 55.0 (Similarity)View   
7ATP1A1AT1A1_HUMANT219DNSSL T GESEP 40.63% Swiss-Prot 55.0 (Similarity)View   
8ATP1A1AT1A1_HUMANS228EPQTR S PDFTN 32.01% Swiss-Prot 55.0 (Similarity)View   
9ATP1A1AT1A1_HUMANY260RGIVV Y TGDRT 8.29% Swiss-Prot 55.0 (Similarity)View   
10ATP1A1AT1A1_HUMANS452VAGDA S ESALL 36.50% Swiss-Prot 55.0 (Similarity)View   
11ATP1A1AT1A1_HUMANS943KTRRN S VFQQG 23.61%PKA_group  Swiss-Prot 55.0 (Similarity) ViewAnalyzing