Regulatory Network in Protein Phosphorylation
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Substrate: CD163

Description: Scavenger receptor cysteine-rich type 1 protein M130 precursor(Hemoglobin scavenger receptor) (CD163 antigen) [Contains: SolubleCD163 (sCD163)].

Synonyms: M130

Ensembl ID: ENSG00000177575

UniprotKB/SwissProt: C163A_HUMAN (Q86VB7)

Function: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. After shedding, the soluble form (sCD163) may play a anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Soluble CD163: Secreted. Cell membrane; Single-pass type I membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CD163

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CD163C163A_HUMANS14LEDSG S ADFRR 28.72% Swiss-Prot 55.0 (Similarity)View   
2CD163C163A_HUMANT1072ALFFL T KKRRQ 29.39%PKCa HPRD:05708(in vitro)  ViewAnalyzing
3CD163C163A_HUMANS1084QRLAV S SRGEN 14.54%PKCa HPRD:05708(in vitro)  ViewAnalyzing
4CD163C163A_HUMANS1085RLAVS S RGENL 37.39%P67870(Casein kinase II, beta) HPRD:05708(in vitro) ViewAnalyzing