|Description: CD44 antigen precursor (Phagocytic glycoprotein I) (PGP-1) (HUTCH-I)(Extracellular matrix receptor-III) (ECMR-III) (GP90 lymphocytehoming/adhesion receptor) (Hermes antigen) (Hyaluronate receptor)(Heparan sulfate proteoglycan) (Epican) (CDw44).|
Synonyms: LHR, MDU2, MDU3, MIC4
Ensembl ID: ENSG00000026508
UniprotKB/SwissProt: CD44_HUMAN (P16070)
Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.