Regulatory Network in Protein Phosphorylation
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Substrate: CD44

Description: CD44 antigen precursor (Phagocytic glycoprotein I) (PGP-1) (HUTCH-I)(Extracellular matrix receptor-III) (ECMR-III) (GP90 lymphocytehoming/adhesion receptor) (Hermes antigen) (Hyaluronate receptor)(Heparan sulfate proteoglycan) (Epican) (CDw44).

Synonyms: LHR, MDU2, MDU3, MIC4

Ensembl ID: ENSG00000026508

UniprotKB/SwissProt: CD44_HUMAN (P16070)

Function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
PDB:1POZ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CD44

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CD44CD44_HUMANS291RDRHL S FSGSG 15.96%PKC_group Phospho.ELM 7.0 ViewAnalyzing
2CD44CD44_HUMANS291RDRHL S FSGSG 15.96% HPRD:00115(in vivo)View   
3CD44CD44_HUMANS672CIAVN S RRRCG 22.14%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
4CD44CD44_HUMANS672CIAVN S RRRCG 22.14% HPRD:00115(in vivo)View   
5CD44CD44_HUMANS672CIAVN S RRRCG 22.14%PKC_group Swiss-Prot 55.0  ViewAnalyzing
6CD44CD44_HUMANS686KLVIN S GNGAV 23.63% Phospho.ELM 7.0View   
7CD44CD44_HUMANS686KLVIN S GNGAV 23.63% Swiss-Prot 55.0 View   
8CD44CD44_HUMANS697EDRKP S GLNGE 59.97% Phospho.ELM 7.0View   
9CD44CD44_HUMANS697EDRKP S GLNGE 59.97% Swiss-Prot 55.0 View   
10CD44CD44_HUMANS706GEASK S QEMVH 28.95% HPRD:00115(in vitro)View   
11CD44CD44_HUMANS706GEASK S QEMVH 28.95% Phospho.ELM 7.0View   
12CD44CD44_HUMANS706GEASK S QEMVH 28.95% Swiss-Prot 55.0 View   
13CD44CD44_HUMANT720KESSE T PDQFM 33.83% Swiss-Prot 55.0 View   
14CD44CD44_HUMANT720KESSE T PDQFM 33.83% Phospho.ELM 7.0View