Regulatory Network in Protein Phosphorylation
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Substrate: CFTR

Description: Cystic fibrosis transmembrane conductance regulator (CFTR) (cAMP-dependent chloride channel) (ATP-binding cassette transporter sub-family C member 7).

Synonyms: ABCC7

Ensembl ID: ENSG00000001626

UniprotKB/SwissProt: CFTR_HUMAN (P13569)

Function: Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein.
PDB:1NBD
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of CFTR

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1CFTRCFTR_HUMANS660AERRN S ILTET 19.70%PKG_group Phospho.ELM 7.0 ViewAnalyzing
2CFTRCFTR_HUMANS660AERRN S ILTET 19.70%PKG1 HPRD:03883(in vitro)  ViewAnalyzing
3CFTRCFTR_HUMANS660AERRN S ILTET 19.70%PKA_group Phospho.ELM 7.0 ViewAnalyzing
4CFTRCFTR_HUMANS660AERRN S ILTET 19.70%PKA_group Swiss-Prot 55.0  ViewAnalyzing
5CFTRCFTR_HUMANS686ETKKQ S FKQTG 43.20%PKC_group Phospho.ELM 7.0 ViewAnalyzing
6CFTRCFTR_HUMANS686ETKKQ S FKQTG 43.20%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
7CFTRCFTR_HUMANS686ETKKQ S FKQTG 43.20%PKCa HPRD:03883(in vitro)  ViewAnalyzing
8CFTRCFTR_HUMANS686ETKKQ S FKQTG 43.20%PKC_group Swiss-Prot 55.0  ViewAnalyzing
9CFTRCFTR_HUMANS700EKRKN S ILNPI 31.33%PKG1 HPRD:03883(in vitro)  ViewAnalyzing
10CFTRCFTR_HUMANS700EKRKN S ILNPI 31.33%PKA_group Phospho.ELM 7.0 ViewAnalyzing
11CFTRCFTR_HUMANS700EKRKN S ILNPI 31.33%PKG_group Phospho.ELM 7.0 ViewAnalyzing
12CFTRCFTR_HUMANS700EKRKN S ILNPI 31.33%PKACa HPRD:03883(in vitro)  ViewAnalyzing
13CFTRCFTR_HUMANS700EKRKN S ILNPI 31.33%PKA_group Swiss-Prot 55.0  ViewAnalyzing
14CFTRCFTR_HUMANS712SIRKF S IVQKT 25.53% Phospho.ELM 7.0View   
15CFTRCFTR_HUMANS712SIRKF S IVQKT 25.53%PKA_group Swiss-Prot 55.0  ViewAnalyzing
16CFTRCFTR_HUMANS737LERRL S LVPDS 26.05%PKG1 HPRD:03883(in vitro)  ViewAnalyzing
17CFTRCFTR_HUMANS737LERRL S LVPDS 26.05%PKA_group Phospho.ELM 7.0 ViewAnalyzing
18CFTRCFTR_HUMANS737LERRL S LVPDS 26.05%PKA_group Swiss-Prot 55.0  ViewAnalyzing
19CFTRCFTR_HUMANS737LERRL S LVPDS 26.05%PKACa HPRD:03883(in vitro)  ViewAnalyzing
20CFTRCFTR_HUMANS737LERRL S LVPDS 26.05%PKG_group Phospho.ELM 7.0 ViewAnalyzing
21CFTRCFTR_HUMANS753ILPRI S VISTG 18.06%PKA_group Swiss-Prot 55.0  ViewAnalyzing
22CFTRCFTR_HUMANS753ILPRI S VISTG 18.06%PKA_group Phospho.ELM 7.0 ViewAnalyzing
23CFTRCFTR_HUMANS768ARRRQ S VLNLM 27.10%PKACa HPRD:03883(in vitro)  ViewAnalyzing
24CFTRCFTR_HUMANS768ARRRQ S VLNLM 27.10%PKA_group Swiss-Prot 55.0  ViewAnalyzing
25CFTRCFTR_HUMANS768ARRRQ S VLNLM 27.10%PKG1 HPRD:03883(in vitro)  ViewAnalyzing
26CFTRCFTR_HUMANS768ARRRQ S VLNLM 27.10%PKG_group Phospho.ELM 7.0 ViewAnalyzing
27CFTRCFTR_HUMANS768ARRRQ S VLNLM 27.10%PKA_group Phospho.ELM 7.0 ViewAnalyzing
28CFTRCFTR_HUMANS790RKTTA S TRKVS 27.01%PKC_group Phospho.ELM 7.0 ViewAnalyzing
29CFTRCFTR_HUMANS790RKTTA S TRKVS 27.01%PKC_group Swiss-Prot 55.0  ViewAnalyzing
30CFTRCFTR_HUMANS790RKTTA S TRKVS 27.01%PKCa HPRD:03883(in vitro)  ViewAnalyzing
31CFTRCFTR_HUMANS795STRKV S LAPQA 23.11%PKG_group Phospho.ELM 7.0 ViewAnalyzing
32CFTRCFTR_HUMANS795STRKV S LAPQA 23.11%PKG1 HPRD:03883(in vitro)  ViewAnalyzing
33CFTRCFTR_HUMANS795STRKV S LAPQA 23.11%PKACa HPRD:03883(in vitro)  ViewAnalyzing
34CFTRCFTR_HUMANS795STRKV S LAPQA 23.11%PKA_group Swiss-Prot 55.0  ViewAnalyzing
35CFTRCFTR_HUMANS795STRKV S LAPQA 23.11%PKA_group Phospho.ELM 7.0 ViewAnalyzing
36CFTRCFTR_HUMANS813YSRRL S QETGL 24.94%PKACa HPRD:03883(in vitro)  ViewAnalyzing
37CFTRCFTR_HUMANS813YSRRL S QETGL 24.94%PKA_group Swiss-Prot 55.0  ViewAnalyzing
38CFTRCFTR_HUMANS813YSRRL S QETGL 24.94%PKG_group Phospho.ELM 7.0 ViewAnalyzing
39CFTRCFTR_HUMANS813YSRRL S QETGL 24.94%PKG1 HPRD:03883(in vitro)  ViewAnalyzing
40CFTRCFTR_HUMANS813YSRRL S QETGL 24.94%PKA_group Phospho.ELM 7.0 ViewAnalyzing