Regulatory Network in Protein Phosphorylation
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Substrate: DGKZ

Description: Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta)(DGK-zeta) (DAG kinase zeta).

Synonyms: DAGK6

Ensembl ID: ENSG00000149091

UniprotKB/SwissProt: DGKZ_HUMAN (Q13574)

Function: Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Isoform 2 but not isoform 1 regulates RASGRP1 activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Cell membrane.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of DGKZ

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1DGKZDGKZ_HUMANS266PGAPC S ESERQ 43.00%PKCa HPRD:03260(in vitro)  ViewAnalyzing
2DGKZDGKZ_HUMANS454KKKRA S FKRKS 35.02%PKCa HPRD:03260(in vitro)  ViewAnalyzing
3DGKZDGKZ_HUMANS686FLMGS S KDLAK 25.18% Swiss-Prot 55.0 View