Regulatory Network in Protein Phosphorylation
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Substrate: EWSR1

Description: RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpointregion 1 protein).

Synonyms: EWS

Ensembl ID: ENSG00000182944

UniprotKB/SwissProt: EWS_HUMAN (Q01844)

Function: Might normally function as a repressor. EWS-fusion- proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Cell surface. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.
PDB:2CPE
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of EWSR1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1EWSR1EWS_HUMANS266YGQQS S FRQDH 21.80%PKC_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2EWSR1EWS_HUMANS266YGQQS S FRQDH 21.80%PKC_group Phospho.ELM 7.0 ViewAnalyzing
3EWSR1EWS_HUMANS266YGQQS S FRQDH 21.80%PKCa HPRD:00592(in vitro)  ViewAnalyzing