|Description: RNA-binding protein EWS (EWS oncogene) (Ewing sarcoma breakpointregion 1 protein).|
Ensembl ID: ENSG00000182944
UniprotKB/SwissProt: EWS_HUMAN (Q01844)
Function: Might normally function as a repressor. EWS-fusion- proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cell surface. Note=Relocates from cytoplasm to ribosomes upon PTK2B/FAK2 activation.