|Description: Proto-oncogene tyrosine-protein kinase Fyn (EC 18.104.22.168) (p59-Fyn)(Protooncogene Syn) (SLK).|
Ensembl ID: ENSG00000010810
UniprotKB/SwissProt: FYN_HUMAN (P06241)
Function: Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.