Regulatory Network in Protein Phosphorylation
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Substrate: FYN

Description: Proto-oncogene tyrosine-protein kinase Fyn (EC (p59-Fyn)(Protooncogene Syn) (SLK).

Ensembl ID: ENSG00000010810

UniprotKB/SwissProt: FYN_HUMAN (P06241)

Function: Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Note=Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of FYN

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1FYNFYN_HUMANT12KDKEA T KLTEE 27.90%PKC_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2FYNFYN_HUMANT12KDKEA T KLTEE 27.90% Phospho.ELM 7.0View   
3FYNFYN_HUMANS21EERDG S LNQSS 28.56% Swiss-Prot 55.0 View   
4FYNFYN_HUMANS21EERDG S LNQSS 28.56% Phospho.ELM 7.0View   
5FYNFYN_HUMANY28NQSSG Y RYGTD 11.56%Fyn Phospho.ELM 7.0  ViewAnalyzing
6FYNFYN_HUMANY28NQSSG Y RYGTD 11.56%PDGFRb Phospho.ELM 7.0  ViewAnalyzing
7FYNFYN_HUMANY28NQSSG Y RYGTD 11.56%PDGFRb HPRD:00655(in vitro)  ViewAnalyzing
8FYNFYN_HUMANY30SSGYR Y GTDPT 18.85%FYN HPRD:00655(in vitro)  ViewAnalyzing
9FYNFYN_HUMANY30SSGYR Y GTDPT 18.85%Fyn Phospho.ELM 7.0  ViewAnalyzing
10FYNFYN_HUMANY39PTPQH Y PSFGV 8.70%Fyn Phospho.ELM 7.0  ViewAnalyzing
11FYNFYN_HUMANY39PTPQH Y PSFGV 8.70%FYN HPRD:00655(in vitro)  ViewAnalyzing
12FYNFYN_HUMANY185TTKGA Y SLSIR 20.86% Swiss-Prot 55.0 (Similarity)View   
13FYNFYN_HUMANY214DNGGY Y ITTRA 8.61% Phospho.ELM 7.0View   
14FYNFYN_HUMANY420IEDNE Y TARQG 16.38%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
15FYNFYN_HUMANY420IEDNE Y TARQG 16.38%FYN HPRD:00655(in vitro)  ViewAnalyzing
16FYNFYN_HUMANY420IEDNE Y TARQG 16.38%Fyn Phospho.ELM 7.0  ViewAnalyzing
17FYNFYN_HUMANY531ATEPQ Y QPGEN 27.65%Csk Phospho.ELM 7.0  ViewAnalyzing
18FYNFYN_HUMANY531ATEPQ Y QPGEN 27.65%CSK HPRD:00655(in vivo)  ViewAnalyzing
19FYNFYN_HUMANY531ATEPQ Y QPGEN 27.65% Swiss-Prot 55.0 View