|Description: Glutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamatereceptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2).|
Ensembl ID: ENSG00000120251
UniprotKB/SwissProt: GRIA2_HUMAN (P42262)
Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.