Regulatory Network in Protein Phosphorylation
[Home] [About] [Browse Kinome] [Phosphorylation Prediction] [Expression Analysis] [Statistics] [Help] Version 1.0

[Back to Kinase PKCi]
Substrate: GRIA2

Description: Glutamate receptor 2 precursor (GluR-2) (GluR-B) (GluR-K2) (Glutamatereceptor ionotropic, AMPA 2) (AMPA-selective glutamate receptor 2).

Synonyms: GLUR2

Ensembl ID: ENSG00000120251

UniprotKB/SwissProt: GRIA2_HUMAN (P42262)

Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of GRIA2

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1GRIA2GRIA2_HUMANS683EFFRR S KIAVF 24.94%PKC_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2GRIA2GRIA2_HUMANS683EFFRR S KIAVF 24.94%PKCa HPRD:04726(in vitro)  ViewAnalyzing
3GRIA2GRIA2_HUMANS717ARVRK S KGKYA 35.76%PKG_group Swiss-Prot 55.0 (Similarity) ViewAnalyzing
4GRIA2GRIA2_HUMANS717ARVRK S KGKYA 35.76%PKCa HPRD:04726(in vitro)  ViewAnalyzing
5GRIA2GRIA2_HUMANY869QNFAT Y KEGYN 12.01% Swiss-Prot 55.0 (Similarity)View   
6GRIA2GRIA2_HUMANY876EGYNV Y GIESV 14.56% Swiss-Prot 55.0 (Similarity)View   
7GRIA2GRIA2_HUMANS880VYGIE S VKI 27.13% Swiss-Prot 55.0 (Similarity)View   
8GRIA2GRIA2_HUMANS880VYGIE S VKI 27.13% Phospho.ELM 7.0View   
9GRIA2GRIA2_HUMANS880VYGIE S VKI 27.13%PKCa HPRD:04726(in vitro;in vivo)  ViewAnalyzing