Regulatory Network in Protein Phosphorylation
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Substrate: GRIA4

Description: Glutamate receptor 4 precursor (GluR-4) (GluR4) (GluR-D) (Glutamatereceptor ionotropic, AMPA 4) (AMPA-selective glutamate receptor 4).

Synonyms: GLUR4

Ensembl ID: ENSG00000152578

UniprotKB/SwissProt: GRIA4_HUMAN (P48058)

Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of GRIA4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1GRIA4GRIA4_HUMANT850KRMKL T FSEAI 21.43%PKCa HPRD:00694(in vivo)  ViewAnalyzing
2GRIA4GRIA4_HUMANT850KRMKL T FSEAI 21.43%PKC_group Phospho.ELM 7.0 ViewAnalyzing
3GRIA4GRIA4_HUMANS862NKARL S ITGSV 16.73%PKCa HPRD:00694(in vitro;in vivo)  ViewAnalyzing
4GRIA4GRIA4_HUMANS862NKARL S ITGSV 16.73%PKACa HPRD:00694(in vitro;in vivo)  ViewAnalyzing
5GRIA4GRIA4_HUMANS862NKARL S ITGSV 16.73%PKC_group Phospho.ELM 7.0 ViewAnalyzing
6GRIA4GRIA4_HUMANS862NKARL S ITGSV 16.73%PKA_group Phospho.ELM 7.0 ViewAnalyzing
7GRIA4GRIA4_HUMANS862NKARL S ITGSV 16.73%CaMK2g HPRD:00694(in vitro;in vivo)  ViewAnalyzing