Regulatory Network in Protein Phosphorylation
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Substrate: GRIK1

Description: Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor5) (GluR-5) (GluR5) (Excitatory amino acid receptor 3) (EAA3).

Synonyms: GLUR5

Ensembl ID: ENSG00000171189

UniprotKB/SwissProt: GRIK1_HUMAN (P39086)

Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of GRIK1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1GRIK1GRIK1_HUMANS725MWAFM S SRQQT 18.86%PKC_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing
2GRIK1GRIK1_HUMANT761SIEYV T QRNCN 22.40%PKC_group  Swiss-Prot 55.0 (Potential) ViewAnalyzing