|Description: Glutamate receptor, ionotropic kainate 1 precursor (Glutamate receptor5) (GluR-5) (GluR5) (Excitatory amino acid receptor 3) (EAA3).|
Ensembl ID: ENSG00000171189
UniprotKB/SwissProt: GRIK1_HUMAN (P39086)
Function: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.