Regulatory Network in Protein Phosphorylation
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Substrate: GRIN1

Description: Glutamate [NMDA] receptor subunit zeta-1 precursor (N-methyl-D-aspartate receptor subunit NR1).

Synonyms: NMDAR1

Ensembl ID: ENSG00000176884

UniprotKB/SwissProt: NMDZ1_HUMAN (Q05586)

Function: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Enriched in post-synaptic plasm
PDB:2NR1
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of GRIN1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1GRIN1NMDZ1_HUMANT879PKKKA T FRAIT 23.64% HPRD:15926(in vitro)View   
2GRIN1NMDZ1_HUMANS889TSTLA S SFKRR 39.15% HPRD:15926(in vitro)View   
3GRIN1NMDZ1_HUMANS889TSTLA S SFKRR 39.15%PKC_group Phospho.ELM 7.0 ViewAnalyzing
4GRIN1NMDZ1_HUMANS889TSTLA S SFKRR 39.15%PKC_group Swiss-Prot 55.0 (Probable) ViewAnalyzing
5GRIN1NMDZ1_HUMANS890STLAS S FKRRR 29.22%PKC_group Swiss-Prot 55.0 (Probable) ViewAnalyzing
6GRIN1NMDZ1_HUMANS890STLAS S FKRRR 29.22% HPRD:15926(in vitro)View   
7GRIN1NMDZ1_HUMANS890STLAS S FKRRR 29.22%PKC_group Phospho.ELM 7.0 ViewAnalyzing
8GRIN1NMDZ1_HUMANS896FKRRR S SKDTS 39.67%PKC_group Phospho.ELM 7.0 ViewAnalyzing
9GRIN1NMDZ1_HUMANS896FKRRR S SKDTS 39.67%PKC_group Swiss-Prot 55.0 (Probable) ViewAnalyzing
10GRIN1NMDZ1_HUMANS896FKRRR S SKDTS 39.67% HPRD:15926(in vitro)View   
11GRIN1NMDZ1_HUMANS897KRRRS S KDTST 32.51%PKC_group Phospho.ELM 7.0 ViewAnalyzing
12GRIN1NMDZ1_HUMANS897KRRRS S KDTST 32.51%PKC_group Swiss-Prot 55.0 (Probable) ViewAnalyzing
13GRIN1NMDZ1_HUMANS897KRRRS S KDTST 32.51% HPRD:15926(in vitro)View