Regulatory Network in Protein Phosphorylation
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Substrate: GRIN2A

Description: Glutamate [NMDA] receptor subunit epsilon-1 precursor (N-methyl D-aspartate receptor subtype 2A) (NR2A) (NMDAR2A) (hNR2A).

Synonyms: NMDAR2A

Ensembl ID: ENSG00000183454

UniprotKB/SwissProt: NMDE1_HUMAN (Q12879)

Function: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of GRIN2A

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1GRIN2ANMDE1_HUMANT888PDFNL T GSQSN 35.57% Swiss-Prot 55.0 (Similarity)View   
2GRIN2ANMDE1_HUMANS912MSNMN S SRMDS 14.46% Swiss-Prot 55.0 View   
3GRIN2ANMDE1_HUMANS917SSRMD S PKRAA 23.99% Swiss-Prot 55.0 View   
4GRIN2ANMDE1_HUMANS929FIQRG S LIMDM 19.53% Swiss-Prot 55.0 (Similarity)View   
5GRIN2ANMDE1_HUMANY943KGNLM Y SDNRS 18.95% Swiss-Prot 55.0 (Similarity)View   
6GRIN2ANMDE1_HUMANS1025SIRQD S LSQNP 22.91% Swiss-Prot 55.0 (Similarity)View   
7GRIN2ANMDE1_HUMANY1105EVERT Y LKTKS 16.66%SRC HPRD:00698(in vivo)  ViewAnalyzing
8GRIN2ANMDE1_HUMANS1232HFTMR S PFKCD 24.70%CDK5 HPRD:00698(in vitro)  ViewAnalyzing
9GRIN2ANMDE1_HUMANS1232HFTMR S PFKCD 24.70%CDK_group Phospho.ELM 7.0 ViewAnalyzing
10GRIN2ANMDE1_HUMANY1267TGEQV Y QQDWA 10.51%SRC HPRD:00698(in vivo)  ViewAnalyzing
11GRIN2ANMDE1_HUMANS1291ISRQH S YDNIV 26.33%CaMK2b HPRD:00698(in vitro;in vivo)  ViewAnalyzing
12GRIN2ANMDE1_HUMANS1291ISRQH S YDNIV 26.33%CaMK2a HPRD:00698(in vitro;in vivo)  ViewAnalyzing
13GRIN2ANMDE1_HUMANS1337PSSKL S GKKSS 52.91% Swiss-Prot 55.0 View   
14GRIN2ANMDE1_HUMANY1387CPSDP Y KHSLP 26.73%SRC HPRD:00698(in vivo)  ViewAnalyzing
15GRIN2ANMDE1_HUMANS1416YCSRD S RGHND 38.77%PKCa HPRD:00698(in vitro;in vivo)  ViewAnalyzing
16GRIN2ANMDE1_HUMANS1459YKKMP S IESDV 35.17% Swiss-Prot 55.0 (Similarity)View