Regulatory Network in Protein Phosphorylation
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Substrate: HAND1

Description: Heart- and neural crest derivatives-expressed protein 1(Extraembryonic tissues, heart, autonomic nervous system and neuralcrest derivatives-expressed protein 1) (eHAND).

Synonyms: EHAND

Ensembl ID: ENSG00000113196

UniprotKB/SwissProt: HAND1_HUMAN (O96004)

Function: Plays an essential role in early trophoblast differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity).
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HAND1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HAND1HAND1_HUMANS98GRRKG S GPKKE 55.76%PKCa HPRD:03871(in vitro;in vivo)  ViewAnalyzing
2HAND1HAND1_HUMANS98GRRKG S GPKKE 55.76%PKC_group Phospho.ELM 7.0 ViewAnalyzing
3HAND1HAND1_HUMANS98GRRKG S GPKKE 55.76%PKA_group Phospho.ELM 7.0 ViewAnalyzing
4HAND1HAND1_HUMANS98GRRKG S GPKKE 55.76%PKACa HPRD:03871(in vitro;in vivo)  ViewAnalyzing
5HAND1HAND1_HUMANT107KERRR T ESINS 32.07%PKCa HPRD:03871(in vitro;in vivo)  ViewAnalyzing
6HAND1HAND1_HUMANT107KERRR T ESINS 32.07%PKA_group Phospho.ELM 7.0 ViewAnalyzing
7HAND1HAND1_HUMANT107KERRR T ESINS 32.07%PKC_group Phospho.ELM 7.0 ViewAnalyzing
8HAND1HAND1_HUMANT107KERRR T ESINS 32.07%PKACa HPRD:03871(in vitro;in vivo)  ViewAnalyzing
9HAND1HAND1_HUMANS109RRRTE S INSAF 26.85%PKCa HPRD:03871(in vitro;in vivo)  ViewAnalyzing
10HAND1HAND1_HUMANS109RRRTE S INSAF 26.85%PKA_group Phospho.ELM 7.0 ViewAnalyzing
11HAND1HAND1_HUMANS109RRRTE S INSAF 26.85%PKACa HPRD:03871(in vitro;in vivo)  ViewAnalyzing
12HAND1HAND1_HUMANS109RRRTE S INSAF 26.85%PKC_group Phospho.ELM 7.0 ViewAnalyzing