Regulatory Network in Protein Phosphorylation
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Substrate: HNRPK

Description: Heterogeneous nuclear ribonucleoprotein K (hnRNP K) (Transformationup-regulated nuclear protein) (TUNP).

Synonyms: HNRNPK

Ensembl ID: ENSG00000165119

UniprotKB/SwissProt: HNRPK_HUMAN (P61978)

Function: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus, nucleoplasm.
PDB:1J5K
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HNRPK

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HNRPKHNRPK_HUMANT3---ME T EQPEE 38.33% HPRD:02834(in vivo)View   
2HNRPKHNRPK_HUMANT3---ME T EQPEE 38.33% Phospho.ELM 7.0View   
3HNRPKHNRPK_HUMANT3---ME T EQPEE 38.33% Swiss-Prot 55.0 View   
4HNRPKHNRPK_HUMANS36QAFKR S RNTDE 30.39% Swiss-Prot 55.0 View   
5HNRPKHNRPK_HUMANS36QAFKR S RNTDE 30.39% Phospho.ELM 7.0View   
6HNRPKHNRPK_HUMANY72ALRTD Y NASVS 16.41%SRC HPRD:02834(in vitro;in vivo)  ViewAnalyzing
7HNRPKHNRPK_HUMANS116GLQLP S PTATS 43.40% HPRD:02834(in vivo)View   
8HNRPKHNRPK_HUMANS116GLQLP S PTATS 43.40% Phospho.ELM 7.0View   
9HNRPKHNRPK_HUMANS116GLQLP S PTATS 43.40% Swiss-Prot 55.0 View   
10HNRPKHNRPK_HUMANS214ILDLI S ESPIK 39.04% Swiss-Prot 55.0 View   
11HNRPKHNRPK_HUMANS216DLISE S PIKGR 25.74%JNK3 HPRD:02834(in vitro)  ViewAnalyzing
12HNRPKHNRPK_HUMANS216DLISE S PIKGR 25.74% Swiss-Prot 55.0 View   
13HNRPKHNRPK_HUMANS216DLISE S PIKGR 25.74%JNK3(MAPK10) Phospho.ELM 7.0 ViewAnalyzing
14HNRPKHNRPK_HUMANY225GRAQP Y DPNFY 31.77%SRC HPRD:02834(in vitro;in vivo)  ViewAnalyzing
15HNRPKHNRPK_HUMANY230YDPNF Y DETYD 21.36%SRC HPRD:02834(in vitro;in vivo)  ViewAnalyzing
16HNRPKHNRPK_HUMANY230YDPNF Y DETYD 21.36%Src Phospho.ELM 7.0  ViewAnalyzing
17HNRPKHNRPK_HUMANY234FYDET Y DYGGF 12.72%SRC HPRD:02834(in vitro;in vivo)  ViewAnalyzing
18HNRPKHNRPK_HUMANY234FYDET Y DYGGF 12.72%Src Phospho.ELM 7.0  ViewAnalyzing
19HNRPKHNRPK_HUMANY236DETYD Y GGFTM 14.56%SRC HPRD:02834(in vitro;in vivo)  ViewAnalyzing
20HNRPKHNRPK_HUMANY236DETYD Y GGFTM 14.56%Src Phospho.ELM 7.0  ViewAnalyzing
21HNRPKHNRPK_HUMANS284DYDDM S PRRGP 23.42%PKCd(PKC delta) Phospho.ELM 7.0 ViewAnalyzing
22HNRPKHNRPK_HUMANS284DYDDM S PRRGP 23.42% Swiss-Prot 55.0 View   
23HNRPKHNRPK_HUMANS284DYDDM S PRRGP 23.42%JNK3 HPRD:02834(in vitro)  ViewAnalyzing
24HNRPKHNRPK_HUMANS284DYDDM S PRRGP 23.42% HPRD:02834(in vivo)View   
25HNRPKHNRPK_HUMANS302GGRGG S RARNL 26.12%PKCd(PKC delta) Phospho.ELM 7.0 ViewAnalyzing
26HNRPKHNRPK_HUMANS302GGRGG S RARNL 26.12%PKCd HPRD:02834(in vitro)  ViewAnalyzing
27HNRPKHNRPK_HUMANS353AIDTW S PSEWQ 22.20%JNK3(MAPK10) Phospho.ELM 7.0 ViewAnalyzing
28HNRPKHNRPK_HUMANS353AIDTW S PSEWQ 22.20%Erk1(MAPK3) Phospho.ELM 7.0 ViewAnalyzing
29HNRPKHNRPK_HUMANS353AIDTW S PSEWQ 22.20%JNK3 HPRD:02834(in vitro)  ViewAnalyzing
30HNRPKHNRPK_HUMANS353AIDTW S PSEWQ 22.20%JNK1(MAPK8) Phospho.ELM 7.0 ViewAnalyzing
31HNRPKHNRPK_HUMANS379AGGRG S YGDLG 25.28% Swiss-Prot 55.0 View   
32HNRPKHNRPK_HUMANY380GGRGS Y GDLGG 19.92%Src Phospho.ELM 7.0  ViewAnalyzing