Regulatory Network in Protein Phosphorylation
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Substrate: HRH1

Description: Histamine H1 receptor.

Ensembl ID: ENSG00000196639

UniprotKB/SwissProt: HRH1_HUMAN (P35367)

Function: In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of HRH1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1HRH1HRH1_HUMANT140YLKYR T KTRAS 33.41%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
2HRH1HRH1_HUMANT142KYRTK T RASAT 30.75%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
3HRH1HRH1_HUMANS396WKRLR S HSRQY 30.33%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
4HRH1HRH1_HUMANS396WKRLR S HSRQY 30.33%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
5HRH1HRH1_HUMANS396WKRLR S HSRQY 30.33%PKG1 Phospho.ELM 7.0  ViewAnalyzing
6HRH1HRH1_HUMANS398RLRSH S RQYVS 23.48%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
7HRH1HRH1_HUMANS398RLRSH S RQYVS 23.48%PKA_group Phospho.ELM 7.0 ViewAnalyzing
8HRH1HRH1_HUMANS398RLRSH S RQYVS 23.48%BARK1(GRK2) Phospho.ELM 7.0 ViewAnalyzing
9HRH1HRH1_HUMANS398RLRSH S RQYVS 23.48%PKG1 Phospho.ELM 7.0  ViewAnalyzing
10HRH1HRH1_HUMANS398RLRSH S RQYVS 23.48%CaMK2a Phospho.ELM 7.0  ViewAnalyzing
11HRH1HRH1_HUMANT478ENFKK T FKRIL 34.67%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing