Regulatory Network in Protein Phosphorylation
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Substrate: INSR

Description: Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen)[Contains: Insulin receptor subunit alpha; Insulin receptor subunitbeta].

Ensembl ID: ENSG00000171105

UniprotKB/SwissProt: INSR_HUMAN (P06213)

Function: This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
PDB:1GAG
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of INSR

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1INSRINSR_HUMANY992PLGPL Y ASSNP 13.94%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
2INSRINSR_HUMANY992PLGPL Y ASSNP 13.94%INSR HPRD:00975(in vitro)  ViewAnalyzing
3INSRINSR_HUMANY992PLGPL Y ASSNP 13.94%InsR Phospho.ELM 7.0  ViewAnalyzing
4INSRINSR_HUMANY999SSNPE Y LSASD 13.76%INSR HPRD:00975(in vitro)  ViewAnalyzing
5INSRINSR_HUMANY999SSNPE Y LSASD 13.76%InsR Phospho.ELM 7.0  ViewAnalyzing
6INSRINSR_HUMANY999SSNPE Y LSASD 13.76%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
7INSRINSR_HUMANY1011FPCSV Y VPDEW 7.03%InsR Phospho.ELM 7.0  ViewAnalyzing
8INSRINSR_HUMANY1011FPCSV Y VPDEW 7.03%autocatalysis  Swiss-Prot 55.0 (Probable) ViewAnalyzing
9INSRINSR_HUMANS1062KTVNE S ASLRE 20.25%PKCa HPRD:00975(in vitro)  ViewAnalyzing
10INSRINSR_HUMANS1062KTVNE S ASLRE 20.25%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
11INSRINSR_HUMANS1064VNESA S LRERI 36.92%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
12INSRINSR_HUMANS1064VNESA S LRERI 36.92%PKCa HPRD:00975(in vitro)  ViewAnalyzing
13INSRINSR_HUMANY1185MTRDI Y ETDYY 19.64%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
14INSRINSR_HUMANY1185MTRDI Y ETDYY 19.64%INSR HPRD:00975(in vivo)  ViewAnalyzing
15INSRINSR_HUMANY1185MTRDI Y ETDYY 19.64%InsR Phospho.ELM 7.0  ViewAnalyzing
16INSRINSR_HUMANY1189IYETD Y YRKGG 16.76%INSR HPRD:00975(in vivo)  ViewAnalyzing
17INSRINSR_HUMANY1189IYETD Y YRKGG 16.76%InsR Phospho.ELM 7.0  ViewAnalyzing
18INSRINSR_HUMANY1189IYETD Y YRKGG 16.76%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
19INSRINSR_HUMANY1190YETDY Y RKGGK 14.52%INSR HPRD:00975(in vivo)  ViewAnalyzing
20INSRINSR_HUMANY1190YETDY Y RKGGK 14.52%InsR Phospho.ELM 7.0  ViewAnalyzing
21INSRINSR_HUMANY1190YETDY Y RKGGK 14.52%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
22INSRINSR_HUMANS1314NKAPE S EELEM 35.00% HPRD:00975(in vivo)View   
23INSRINSR_HUMANS1332VPLDR S SHCQR 24.89% Phospho.ELM 7.0View   
24INSRINSR_HUMANS1333PLDRS S HCQRE 29.22% Phospho.ELM 7.0View   
25INSRINSR_HUMANS1348RDGGS S LGFKR 35.47% Phospho.ELM 7.0View   
26INSRINSR_HUMANS1348RDGGS S LGFKR 35.47% HPRD:00975(in vivo)View   
27INSRINSR_HUMANS1354LGFKR S YEEHI 37.17% HPRD:00975(in vitro)View   
28INSRINSR_HUMANS1354LGFKR S YEEHI 37.17% Phospho.ELM 7.0View   
29INSRINSR_HUMANY1355GFKRS Y EEHIP 29.39%InsR Phospho.ELM 7.0  ViewAnalyzing
30INSRINSR_HUMANY1355GFKRS Y EEHIP 29.39%INSR HPRD:00975(in vitro)  ViewAnalyzing
31INSRINSR_HUMANY1355GFKRS Y EEHIP 29.39%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
32INSRINSR_HUMANY1361EEHIP Y THMNG 14.52%autocatalysis Swiss-Prot 55.0  ViewAnalyzing
33INSRINSR_HUMANY1361EEHIP Y THMNG 14.52%InsR Phospho.ELM 7.0  ViewAnalyzing
34INSRINSR_HUMANY1361EEHIP Y THMNG 14.52%INSR HPRD:00975(in vitro)  ViewAnalyzing
35INSRINSR_HUMANT1362EHIPY T HMNGG 14.86%PKCa HPRD:00975(in vitro)  ViewAnalyzing
36INSRINSR_HUMANT1375NGRIL T LPRSN 32.14%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
37INSRINSR_HUMANT1375NGRIL T LPRSN 32.14% HPRD:00975(in vitro)View   
38INSRINSR_HUMANT1375NGRIL T LPRSN 32.14%PKC_group Phospho.ELM 7.0 ViewAnalyzing