Regulatory Network in Protein Phosphorylation
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Substrate: ITGB7

Description: Integrin beta-7 precursor.

Ensembl ID: ENSG00000139626

UniprotKB/SwissProt: ITB7_HUMAN (P26010)

Function: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is expected to play a role in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha-4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 (HML-1) is a receptor for E- cadherin.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
PDB:2BRQ
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of ITGB7

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1ITGB7ITB7_HUMANY778DSNPL Y KSAIT 12.26%Tyr-kinases Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2ITGB7ITB7_HUMANT783YKSAI T TTINP 20.01% Phospho.ELM 7.0View   
3ITGB7ITB7_HUMANT783YKSAI T TTINP 20.01%PKCd HPRD:00948(in vitro)  ViewAnalyzing
4ITGB7ITB7_HUMANT783YKSAI T TTINP 20.01%PKCb HPRD:00948(in vitro)  ViewAnalyzing