Regulatory Network in Protein Phosphorylation
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Substrate: KCNE1

Description: Potassium voltage-gated channel subfamily E member 1 (IKs producingslow voltage-gated potassium channel subunit beta Mink) (Minimalpotassium channel) (Delayed rectifier potassium channel subunit IsK).

Ensembl ID: ENSG00000180509

UniprotKB/SwissProt: KCNE1_HUMAN (P15382)

Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of KCNE1

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1KCNE1KCNE1_HUMANS102ARVLE S YRSCY 22.99%PKC_group  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
2KCNE1KCNE1_HUMANS102ARVLE S YRSCY 22.99%PKCa HPRD:01442(in vitro)  ViewAnalyzing