|Description: Potassium voltage-gated channel subfamily E member 1 (IKs producingslow voltage-gated potassium channel subunit beta Mink) (Minimalpotassium channel) (Delayed rectifier potassium channel subunit IsK).|
Ensembl ID: ENSG00000180509
UniprotKB/SwissProt: KCNE1_HUMAN (P15382)
Function: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.