|Description: Inward rectifier potassium channel 4 (Potassium channel, inwardlyrectifying subfamily J member 4) (Inward rectifier K(+) channelKir2.3) (Hippocampal inward rectifier) (HIR) (HRK1) (HIRK2).|
Ensembl ID: ENSG00000168135
UniprotKB/SwissProt: IRK4_HUMAN (P48050)
Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane; Multi-pass membrane protein.