Regulatory Network in Protein Phosphorylation
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Substrate: KCNJ4

Description: Inward rectifier potassium channel 4 (Potassium channel, inwardlyrectifying subfamily J member 4) (Inward rectifier K(+) channelKir2.3) (Hippocampal inward rectifier) (HIR) (HRK1) (HIRK2).

Ensembl ID: ENSG00000168135

UniprotKB/SwissProt: IRK4_HUMAN (P48050)

Function: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of KCNJ4

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1KCNJ4IRK4_HUMANT53TTCVD T RWRYM 16.25%PKCd(PKC delta) Phospho.ELM 7.0 ViewAnalyzing