Regulatory Network in Protein Phosphorylation
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Substrate: KIT

Description: Mast/stem cell growth factor receptor precursor (EC (SCFR)(Proto-oncogene tyrosine-protein kinase Kit) (c-kit) (CD117 antigen).

Ensembl ID: ENSG00000157404

UniprotKB/SwissProt: KIT_HUMAN (P10721)

Function: This is the receptor for stem cell factor (mast cell growth factor). It has a tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase (Pi3K).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Single-pass type I membrane protein.
Protein Domain and Phosphorylation Sites:

The phosphorylated sites of KIT

No.SubstrateUniProtKB IDPositionPhosphoPeptideSolvent AccessibilityCatalytic kinaseSourceComputational Annotation of Catalytic KinaseInteracting PartnersExpression Analysis
1KITKIT_HUMANY545VMILT Y KYLQK 8.32% HPRD:01287(in vitro)View   
2KITKIT_HUMANY547ILTYK Y LQKPM 12.17% HPRD:01287(in vitro)View   
3KITKIT_HUMANY553LQKPM Y EVQWK 22.83% HPRD:01287(in vitro)View   
4KITKIT_HUMANY568INGNN Y VYIDP 9.91%Kit Phospho.ELM 7.0  ViewAnalyzing
5KITKIT_HUMANY568INGNN Y VYIDP 9.91%KIT HPRD:01287(in vitro)  ViewAnalyzing
6KITKIT_HUMANY568INGNN Y VYIDP 9.91% Swiss-Prot 55.0 (Similarity)View   
7KITKIT_HUMANY570GNNYV Y IDPTQ 6.83%Kit Phospho.ELM 7.0  ViewAnalyzing
8KITKIT_HUMANY570GNNYV Y IDPTQ 6.83% Swiss-Prot 55.0 (Similarity)View   
9KITKIT_HUMANY570GNNYV Y IDPTQ 6.83%KIT HPRD:01287(in vitro)  ViewAnalyzing
10KITKIT_HUMANY703AEAAL Y KNLLH 7.97%KIT HPRD:01287(in vitro)  ViewAnalyzing
11KITKIT_HUMANY703AEAAL Y KNLLH 7.97%Kit Phospho.ELM 7.0  ViewAnalyzing
12KITKIT_HUMANY703AEAAL Y KNLLH 7.97% Swiss-Prot 55.0 (Similarity)View   
13KITKIT_HUMANY721DSTNE Y MDMKP 10.65% Phospho.ELM 7.0View   
14KITKIT_HUMANY721DSTNE Y MDMKP 10.65% HPRD:01287(in vitro)View   
15KITKIT_HUMANY730KPGVS Y VVPTK 11.76% HPRD:01287(in vitro)View   
16KITKIT_HUMANS741ADKRR S VRIGS 21.56%PKCa HPRD:01287(in vitro;in vivo)  ViewAnalyzing
17KITKIT_HUMANS741ADKRR S VRIGS 21.56%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
18KITKIT_HUMANS746SVRIG S YIERD 22.14%PKCa HPRD:01287(in vitro;in vivo)  ViewAnalyzing
19KITKIT_HUMANS746SVRIG S YIERD 22.14%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
20KITKIT_HUMANY747VRIGS Y IERDV 11.11% HPRD:01287(in vitro)View   
21KITKIT_HUMANS821DIKND S NYVVK 39.18%PKCa HPRD:01287(in vivo)  ViewAnalyzing
22KITKIT_HUMANS821DIKND S NYVVK 39.18%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing
23KITKIT_HUMANY823KNDSN Y VVKGN 15.57%autocatalysis  Swiss-Prot 55.0 (Similarity) ViewAnalyzing
24KITKIT_HUMANY823KNDSN Y VVKGN 15.57% Phospho.ELM 7.0View   
25KITKIT_HUMANY900APAEM Y DIMKT 8.20%SRC HPRD:01287(in vitro)  ViewAnalyzing
26KITKIT_HUMANY900APAEM Y DIMKT 8.20%Src Phospho.ELM 7.0  ViewAnalyzing
27KITKIT_HUMANY900APAEM Y DIMKT 8.20%Src_group Phospho.ELM 7.0 ViewAnalyzing
28KITKIT_HUMANY936STNHI Y SNLAN 5.51% Swiss-Prot 55.0 (Similarity)View   
29KITKIT_HUMANY936STNHI Y SNLAN 5.51%KIT HPRD:01287(in vitro)  ViewAnalyzing
30KITKIT_HUMANY936STNHI Y SNLAN 5.51%Kit Phospho.ELM 7.0  ViewAnalyzing
31KITKIT_HUMANS959SVRIN S VGSTA 26.03%PKCa HPRD:01287(in vivo)  ViewAnalyzing
32KITKIT_HUMANS959SVRIN S VGSTA 26.03%PKCa(PKC alpha) Phospho.ELM 7.0 ViewAnalyzing